ArticleThe Science of the total environment2015
Evaluating the effect of ambient particulate pollution on DNA methylation in Alaskan sled dogs: potential applications for a sentinel model of human health.
Article in The Science of the total environment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Responding to Climate and Environmental Change Impacts on Human Health via Integrated Surveillance in the Circumpolar North: A Systematic Realist Review.International journal of environmental research and public health · 2018Pooled it
- The effects of ambient air pollution exposure on Thoroughbred racehorse performance.Equine veterinary journal · 2025Article
- Polyunsaturated fatty acids, vitamin E and lycopene alleviate ambient particulate matter organic extracts-induced oxidative stress in canine lung cells via the Nrf2/HO-1 pathway.Veterinary research communications · 2023Article
- Ambient particulate matter (PMHeliyon · 2022Article
- An observational study of the role of indoor air pollution in pets with naturally acquired bronchial/lung disease.Veterinary medicine and science · 2020Article
- Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila.Scientific reports · 2017Article
- Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation.Frontiers in psychology · 2017Article
- Using Domestic and Free-Ranging Arctic Canid Models for Environmental Molecular Toxicology Research.Environmental science & technology · 2016Article
- The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome.International journal of nanomedicineReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundExposure to ambient particulate matter (PM) is known to be associated with increased morbidity and mortality in human populations. During the winter months in Fairbanks, Alaska, severe temperature inversions lead to elevated concentrations of ambient PM smaller than 2.5 μm (PM2.5). Sled dogs represent an easily accessible environmentally exposed population that may yield findings informative for human health risk assessment.
objectivesIn this pilot study, we evaluated whether ambient PM was associated with markers of global methylation in sled dogs.
methodsKennels were strategically recruited to provide a wide PM2.5 exposure gradient for the Fairbanks area. Continuous monitoring of ambient PM2.5 was conducted at each kennel during the winter of 2012/13 using a DustTrak 8530. Dogs received a physical examination and assessment of standard hematology and clinical chemistries. Global methylation was determined using the LUminometric Methylation Assay (LUMA) and 5-Methycytosine (5-mC) quantification.
resultsThree sled dog kennels (n~30 dogs/kennel) were evaluated and sampled. The average PM2.5 concentrations measured for kennels A, B, and C were 90 μg/m(3), 48 μg/m(3), 16 μg/m(3) (p<0.0001), respectively. The average (standard deviation) global methylation percentage for each kennel measured by LUMA was 76.22 (1.85), 76.52 (1.82), and 76.72 (2.26), respectively. The average (standard deviation) global methylation percentage for each kennel measured by 5-mC was 0.16 (0.04), 0.15 (0.04), and 0.15 (0.05), respectively. There was no statistically significant difference between the three kennels and their average global methylation percentage either by LUMA or 5-mC.
conclusionsIn this study we evaluated global methylation using LUMA and 5-mC and found no differences between kennels, though exposure to ambient PM2.5 was significantly different between kennels. As more information becomes available regarding immunologically-related canine genes and functionally active promoter subunits, the utility of this surrogate could increase.
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