ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2015
Hip Fractures Risk in Older Men and Women Associated With DXA-Derived Measures of Thigh Subcutaneous Fat Thickness, Cross-Sectional Muscle Area, and Muscle Density.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAXJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Pooled it
- Measures of Physical Performance and Muscle Strength as Predictors of Fracture Risk Independent of FRAX, Falls, and aBMD: A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Pooled it
- Prevalence of Sarcopenia and Its Relationship with Sites of Fragility Fractures in Elderly Chinese Men and Women.PloS one · 2015Trial
- Association of immune checkpoint inhibitors with muscle mass and density in patients with melanoma.The oncologist · 2026Article
- Association of computed tomography (CT)-derived muscle area and density at multiple sites with 10-year fracture risk in older men.JBMR plus · 2026Article
- A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium.Life medicine · 2025Article
- The role of proximal femoral bone, muscle and subcutaneous adipose tissue in the discriminating of hip fracture types in elderly women.BMC musculoskeletal disorders · 2025Article
- Sex-specific associations of fat and lean indices with vertebral fractures.Scientific reports · 2025Article
- Prediction of abnormal bone mass with a pericoronary adipose tissue Attenuation model.BMC geriatrics · 2025Article
- Does the Instability of Pertrochanteric Fractures in the Elderly Correlate With Weakened Gluteal Muscles?Cureus · 2024Article
- Relationship between muscle and subcutaneous adipose tissue size and density and proximal femur bone in elderly women with hip fracture.Aging clinical and experimental research · 2024Article
- Muscle parameters in fragility fracture risk prediction in older adults: A scoping review.Journal of cachexia, sarcopenia and muscle · 2024Article
- Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study.Archives of public health = Archives belges de sante publique · 2023Article
- Menopause-Related Changes in Body Composition Are Associated With Subsequent Bone Mineral Density and Fractures: Study of Women's Health Across the Nation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Sex Specific Global Burden of Osteoporosis in 204 Countries and Territories, from 1990 to 2030: An Age-Period-Cohort Modeling Study.The journal of nutrition, health & aging · 2023Article
- Article
- The Inverse Association of Leg Fat Mass and Osteoporosis in Individuals with Type 2 Diabetes Independent of Lean Mass.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Interactive effect of sarcopenia and falls on vertebral osteoporotic fracture in patients with rheumatoid arthritis.Archives of osteoporosis · 2021Article
- Predictive Value of DXA Appendicular Lean Mass for Incident Fractures, Falls, and Mortality, Independent of Prior Falls, FRAX, and BMD: Findings from the Women's Health Initiative (WHI).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Association of Low Muscle Density With Deteriorations in Muscle Strength and Physical Functioning in Rheumatoid Arthritis.Arthritis care & research · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Mid-thigh cross-sectional muscle area (CSA), muscle attenuation, and greater trochanter soft tissue thickness have been shown to be independent risk factors of hip fracture. Our aim was to determine whether muscle and adipose tissue measures derived from dual-energy X-ray absorptiometry (DXA) scans would have a similar risk association as those measured using other imaging methods. Using a case-cohort study design, we identified 169 incident hip fracture cases over an average of 13.5 years among participants from the Health ABC Study, a prospective study of 3075 individuals initially aged 70 to 79 years. We modeled the thigh 3D geometry and compared DXA and computed tomography (CT) measures. DXA-derived thigh CSA, muscle attenuation, and subcutaneous fat thickness were found to be highly correlated to their CT counterparts (Pearson's r = 0.82, 0.45, and 0.91, respectively; p < 0.05). The fracture risk of men and women were calculated separately. We found that decreased subcutaneous fat, CT thigh muscle attenuation, and appendicular lean mass by height squared (ALM/Ht(2)) were associated with fracture risk in men; hazard ratios (HR) = 1.44 (1.02, 2.02), 1.40 (1.05, 1.85), and 0.58 (0.36, 0.91), respectively, after adjusting for age, race, clinical site, body mass index (BMI), chronic disease, hip bone mineral density (BMD), self-reported health, alcohol use, smoking status, education, physical activity, and cognitive function. In a similar model for women, only decreases in subcutaneous fat and DXA CSA were associated with hip fracture risk; HR = 1.39 (1.07, 1.82) and 0.78 (0.62, 0.97), respectively. Men with a high ALM/Ht(2) and low subcutaneous fat thickness had greater than 8 times higher risk for hip fracture compared with those with low ALM/Ht(2) and high subcutaneous fat. In women, ALM/Ht(2) did not improve the model when subcutaneous fat was included. We conclude that the DXA-derived subcutaneous fat thickness is a strong marker for hip fracture risk in both men and women, especially in men with high ALM/Ht(2).
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