Evidence map›Paper›PMID 25644384›Full record

SynthesisMolecular psychiatry2015

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).

G Davies, N Armstrong, J C Bis, J Bressler, V Chouraki, S Giddaluru, E Hofer, C A Ibrahim-Verbaas, M Kirin, J Lahti and 119 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 22 pooled it
46.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 22 syntheses or guidelines pooled it, 408 citations in OpenAlex.

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144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

129 authors at 20 institutions in 13 countries.

G Davies1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Department of Psychology, University of Edinburgh, Edinburgh, UK.
N ArmstrongSchool of Mathematics and Statistics, University of Sydney, Sydney, NSW, Australia.
J C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
J BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
V Chouraki1] Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique, Lille, France [2] Department of Neurology, Boston University School of Medicine, Boston, MA, USA.ORCID 0000000246981794
S Giddaluru1] K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway [2] Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
E Hofer1] Department of Neurology, Medical University of Graz, Graz, Austria [2] Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
C A Ibrahim-Verbaas1] Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
M KirinCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
J Lahti1] Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland [2] Folkhälsan Research Centre, Helsinki, Finland.
S J van der LeeGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
S Le Hellard1] K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway [2] Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
T Liu1] Max Planck Institute for Human Development, Berlin, Germany [2] Max Planck Institute for Molecular Genetics, Berlin, Germany.
R E Marioni1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK [3] Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
C OldmeadowHunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.
I Postmus1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
A V Smith1] Icelandic Heart Association, Kopavogur, Iceland [2] University of Iceland, Reykjavik, Iceland.
J A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
A ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
R ThomsonMenzies Research Institute, Hobart, Tasmania.
V VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
J Wang1] Framingham Heart Study, Framingham, MA, USA [2] Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
L YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
L Zgaga1] Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland [2] Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.
W ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
R BoxallMedical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
S E Harris1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
W D HillDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
D C LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
M Luciano1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Department of Psychology, University of Edinburgh, Edinburgh, UK.
H Adams1] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.ORCID 0000000336872508
D Ames1] National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, VIC, Australia [2] Academic Unit for Psychiatry of Old Age, St George's Hospital, University of Melbourne, Kew, Australia.
N Amin1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
P AmouyelInserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique, Lille, France.ORCID 000000019088234X
A A AssarehCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
R Au1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] Framingham Heart Study, Framingham, MA, USA.
J T Becker1] Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA [3] Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
A Beiser1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] Framingham Heart Study, Framingham, MA, USA.
C Berr1] Inserm, U106, Montpellier, France [2] Université Montpellier I, Montpellier, France.
L Bertram1] Max Planck Institute for Molecular Genetics, Berlin, Germany [2] Faculty of Medicine, School of Public Health, Imperial College, London, UK.
E Boerwinkle1] Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA [2] Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, TX, USA [3] Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
B M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
H CampbellCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
J CorleyDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
P L De Jager1] Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA [2] Harvard Medical School, Boston, MA, USA [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
C Dufouil1] Inserm U708, Neuroepidemiology, Paris, France [2] Inserm U897, Université Bordeaux Segalen, Bordeaux, France.
J G Eriksson1] Folkhälsan Research Centre, Helsinki, Finland [2] National Institute for Health and Welfare, Helsinki, Finland [3] Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland [4] Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.
T Espeseth1] K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Department of Psychology, University of Oslo, Oslo, Norway.
J D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
I FordRobertson Center for Biostatistics, Glasgow, UK.
Generation ScotlandGeneration Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
R F GottesmanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
M E GriswoldCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA.
V Gudnason1] Icelandic Heart Association, Kopavogur, Iceland [2] University of Iceland, Reykjavik, Iceland.
T B HarrisIntramural Research Program National Institutes on Aging, National Institutes of Health, Bethesda, MD, USA.
G HeissDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
A Hofman1] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
E G HollidayHunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.
J HuffmanMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000000296722491
S L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
N Kochan1] Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia [2] Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
D S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
J B Kwok1] Neuroscience Research Australia, Randwick, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
J-C LambertInserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique, Lille, France.
T Lee1] Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia [2] Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
G LiCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
S-C Li1] Max Planck Institute for Human Development, Berlin, Germany [2] Technische Universität Dresden, Dresden, Germany.
M LoitfelderDepartment of Neurology, Medical University of Graz, Graz, Austria.
O L LopezDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
A J Lundervold1] Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway [2] Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway [3] K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
A LundqvistUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
K A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
S S Mirza1] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
L Nyberg1] Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden [2] Department of Radiation Sciences, Umeå University, Umeå, Sweden [3] Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.
B A OostraGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
A Palotie1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK [2] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [3] Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.
G Papenberg1] Max Planck Institute for Human Development, Berlin, Germany [2] Karolinska Institutet, Aging Research Center, Stockholm University, Stockholm, Sweden.
A PattieDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
K PetrovicDepartment of Neurology, Medical University of Graz, Graz, Austria.
O PolasekFaculty of Medicine, Department of Public Health, University of Split, Split, Croatia.
B M Psaty1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA [2] Deparment of Epidemiology, University of Washington, Seattle, WA, USA [3] Deparment of Health Services, University of Washington, Seattle, WA, USA [4] Group Health Research Unit, Group Health Cooperative, Seattle, WA, USA.
P RedmondDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
S ReppermundCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
J I Rotter1] Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center, Los Angeles, CA, USA [2] Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA, USA.
H Schmidt1] Department of Neurology, Medical University of Graz, Graz, Austria [2] Centre for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
M Schuur1] Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
P W SchofieldSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
R J ScottHunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.
V M Steen1] K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway [2] Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
D J StottInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
J C van SwietenDepartment of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
K D Taylor1] Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center, Los Angeles, CA, USA [2] Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA, USA.
J Trollor1] Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia [2] Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
S Trompet1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands [2] Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
A G Uitterlinden1] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands [3] Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
G Weinstein1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] Framingham Heart Study, Framingham, MA, USA.
E WidenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
B G WindhamDivision of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
J W Jukema1] Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands [2] Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands [3] Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands.
A F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
M J WrightNeuroimaging Genetics Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Q Yang1] Framingham Heart Study, Framingham, MA, USA [2] Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
H AmievaInserm U897, Université Bordeaux Segalen, Bordeaux, France.
J R AttiaHunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.
D A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
H Brodaty1] Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia [2] Dementia Collaborative Research Centre, University of New South Wales, Sydney, NSW, Australia.
A J M de Craen1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
C HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
M A Ikram1] Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands [3] Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands [4] Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
U LindenbergerMax Planck Institute for Human Development, Berlin, Germany.
L-G NilssonARC, Karolinska Institutet, Stockholm and UFBI, Umeå University, Umeå, Sweden.
D J Porteous1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK [3] Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
K RäikkönenInstitute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
I ReinvangDepartment of Psychology, University of Oslo, Oslo, Norway.
I RudanCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000000169936884
P S Sachdev1] Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia [2] Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
R SchmidtDepartment of Neurology, Medical University of Graz, Graz, Austria.
P R Schofield1] Neuroscience Research Australia, Sydney, NSW, Australia [2] Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
V Srikanth1] Menzies Research Institute, Hobart, Tasmania [2] Stroke and Ageing Research, Medicine, Southern Clinical School, Monash University, Melbourne, VIC, Australia.
J M Starr1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
S T TurnerDivision of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
D R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
J F WilsonCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
C van Duijn1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
L LaunerIntramural Research Program National Institutes on Aging, National Institutes of Health, Bethesda, MD, USA.
A L Fitzpatrick1] Deparment of Epidemiology, University of Washington, Seattle, WA, USA [2] Department of Global Health, University of Washington, Seattle, WA, USA.
S Seshadri1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] Framingham Heart Study, Framingham, MA, USA.
T H MosleyDivision of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
I J Deary1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Department of Psychology, University of Edinburgh, Edinburgh, UK.
Erasmus MC · NLUniversity of Edinburgh · GBUNSW Sydney · AUFramingham Heart Study · USInserm · FRMedical University of Graz · ATUniversity of Helsinki · FIUniversity of Michigan · USHunter Medical Research Institute · AUInstitute of Genetics and Cancer · GBLeiden University Medical Center · NLWestern General Hospital · GBHaukeland University Hospital · NOMax Planck Institute for Human Development · DENew South Wales Department of Health · AUUniversity of Mississippi Medical Center · USUniversity of Washington · USMayo Clinic · USNational Institutes of Health · USRush University Medical Center · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Risk Factors, Pathology, and Clinical Expressions of ADRF1AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2014 to 2014
$6.0M
The ARIC and Neurocognitive Longitudinal StudyR01HL070825 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI MOSLEY, THOMAS H · 2002 to 2004
$5.1M
Biotechnology and Biological Sciences Research Council BB/F019394/1Biotechnology and Biological Sciences Research Council S18386Chief Scientist Office CZB/4/505Chief Scientist Office CZB/4/710Chief Scientist Office CZD/16/6/4Chief Scientist Office ETM/55Medical Research Council G0700704Medical Research Council MC_PC_U127561128Medical Research Council MR/K026992/1
6 · The paper itself

Abstract

General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53,949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10(-9), MIR2113; rs17522122, P=2.55 × 10(-8), AKAP6; rs10119, P=5.67 × 10(-9), APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10(-6)). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10(-17)). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.

Indexed as

AgedAged, 80 and overAtherosclerosisCognitionCognition DisordersCohort StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHMGN1 ProteinHumansMaleMiddle AgedNeuropsychological TestsPhenotypePolymorphism, Single NucleotideHMGN1 Protein

Identifiers

PMID25644384
PMCPMC4356746
OpenAlexW2112658198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.