ArticleJournal of the American Society of Nephrology : JASN2015
Developmental Programming of Branching Morphogenesis in the Kidney.
Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Article
- Participation of Endothelin in the postnatal development of the rat kidney: Molecular mechanisms involved.PloS one · 2026Article
- Low nephron endowment increases susceptibility to renal stress and chronic kidney disease.JCI insight · 2023Article
- The developing murine kidney actively negotiates geometric packing conflicts to avoid defects.Developmental cell · 2023Article
- Prenatal and early childhood critical windows for the association of nephrotoxic metal and metalloid mixtures with kidney function.Environment international · 2022Article
- Impact of early life development on later onset chronic kidney disease and hypertension and the role of evolutionary trade-offs.Experimental physiology · 2022Review
- Critical windows of perinatal particulate matter (PMEnvironmental research · 2022Article
- Review
- Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKD.Kidney360 · 2020Review
- Circadian Clock Regulation of Developmental Time in the Kidney.Cell reports · 2020Article
- Simple Rules Determine Distinct Patterns of Branching Morphogenesis.Cell systems · 2019Article
- Evolution, kidney development, and chronic kidney disease.Seminars in cell & developmental biology · 2019Review
- Spontaneous calcium activity in metanephric mesenchymal cells regulates branching morphogenesis in the embryonic kidney.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Statistical theory of branching morphogenesis.Development, growth & differentiation · 2018Review
- Turing Instability-Driven Biofabrication of Branching Tissue Structures: A Dynamic Simulation and Analysis Based on the Reaction⁻Diffusion MechanismMicromachines · 2018Article
- Evolution and Kidney Development: A Rosetta Stone for Nephrology.Journal of the American Society of Nephrology : JASN · 2018Article
- Branching morphogenesis of the urinary collecting system in the human embryonic metanephros.PloS one · 2018Article
- Mathematical Approaches of Branching Morphogenesis.Frontiers in genetics · 2018Review
- Developmental Programming of Renal Function and Re-Programming Approaches.Frontiers in pediatrics · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The kidney developmental program encodes the intricate branching and organization of approximately 1 million functional units (nephrons). Branching regulation is poorly understood, as is the source of a 10-fold variation in nephron number. Notably, low nephron count increases the risk for developing hypertension and renal failure. To better understand the source of this variation, we analyzed the complete gestational trajectory of mouse kidney development. We constructed a computerized architectural map of the branching process throughout fetal life and found that organogenesis is composed of two distinct developmental phases, each with stage-specific rate and morphologic parameters. The early phase is characterized by a rapid acceleration in branching rate and by branching divisions that repeat with relatively reproducible morphology. The latter phase, however, is notable for a significantly decreased yet constant branching rate and the presence of nonstereotyped branching events that generate progressive variability in tree morphology until birth. Our map identifies and quantitates the contribution of four developmental mechanisms that guide organogenesis: growth, patterning, branching rate, and nephron induction. When applied to organs that developed under conditions of malnutrition or in the setting of growth factor mutation, our normative map provided an essential link between kidney architecture and the fundamental morphogenetic mechanisms that guide development. This morphogenetic map is expected to find widespread applications and help identify modifiable targets to prevent developmental programming of common diseases.
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