ArticleJournal of the American Geriatrics Society2015
Respiratory symptoms, spirometric respiratory impairment, and respiratory disease in middle-aged and older persons.
Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers.Chest · 2022Trial
- Evaluation of Clinical Characteristics and Lung Function Trajectories in Young COPD Patients Within the General Population.International journal of chronic obstructive pulmonary disease · 2026Article
- Baseline Knee Osteoarthritis and Chronic Obstructive Pulmonary Disease as Predictors of Physical Activity Decline: A Five-Year Longitudinal Study in U.S. Adults Using the Disablement Process Framework.Healthcare (Basel, Switzerland) · 2025Article
- Self-reported exposure to dust and diesel exhaust, respiratory symptoms, and use of respiratory protective equipment among Arctic miners.International journal of circumpolar health · 2024Article
- Association between body mass index and respiratory symptoms in US adults: a national cross-sectional study.Scientific reports · 2024Article
- Inspiratory versus expiratory incentive spirometry: A randomised control trial study protocol.The South African journal of physiotherapy · 2023Article
- A novel locus for exertional dyspnoea in childhood asthma.The European respiratory journal · 2021Article
- Lung Function and Respiratory Symptoms after Tuberculosis in an American Indian Population. The Strong Heart Study.Annals of the American Thoracic Society · 2020Article
- Association of Symptoms of Obstructive Lung Disease and All-Cause Mortality in Older Adult Smokers.Journal of the American Geriatrics Society · 2019Article
- Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study.American journal of respiratory and critical care medicine · 2018Observational
- Diagnosis of the cause of chronic dyspnoea in primary and tertiary care: characterizing diagnostic confidence.Journal of thoracic disease · 2018Article
- The outcome and the influencing factors of the age of onset in post-mortem of chronic bronchitis patients: a retrospective study.International journal of chronic obstructive pulmonary disease · 2018Article
- The Global Lung Function Initiative (GLI) Network: bringing the world's respiratory reference values together.Breathe (Sheffield, England) · 2017Review
- Spirometry, Static Lung Volumes, and Diffusing Capacity.Respiratory care · 2017Article
- Dyspnea in Community-Dwelling Older Persons: A Multifactorial Geriatric Health Condition.Journal of the American Geriatrics Society · 2016Article
- Phenotype of Spirometric Impairment in an Aging Population.American journal of respiratory and critical care medicine · 2016Article
- Review
- Phenotype of normal spirometry in an aging population.American journal of respiratory and critical care medicine · 2015Article
- Lower Extremity Proximal Muscle Function and Dyspnea in Older Persons.Journal of the American Geriatrics Society · 2015Article
- Diffusing capacity in normal-for-age spirometry and spirometric impairments, using reference equations from the global lung function initiative.Respiratory medicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo evaluate whether a novel definition of spirometric respiratory impairment from the Global Lung Initiative (GLI) is strongly associated with respiratory symptoms and, in turn, frequently establishes symptomatic respiratory disease.
designCross-sectional.
settingThird National Health and Nutrition Examination Survey.
participantsCommunity-dwelling individuals aged 40 to 80 (N = 7,115). MEASUREMENTS: GLI-defined spirometric respiratory impairment (airflow obstruction and restrictive pattern), dyspnea on exertion (DOE), chronic bronchitis (CB), and wheezing.
resultsPrevalence rates were 12.7% for airflow obstruction, 6.2% for restrictive pattern, 28.6% for DOE, 12.6% for CB, and 12.9% for wheezing. Airflow obstruction was associated with DOE (adjusted odds ratio (aOR) = 1.69, 95% confidence interval (CI) = 1.42-2.02), CB (aOR = 1.92, 95% CI = 1.62-2.29), and wheezing (aOR = 2.50, 95% CI = 2.08-3.00), and restrictive pattern was associated with DOE (aOR = 1.75, 95% CI = 1.36-2.25), CB (aOR = 1.39, 95% CI = 1.08-1.78), and wheezing (aOR = 1.53, 95% CI = 1.15-2.04). Nonetheless, among participants who had airflow obstruction and restrictive pattern, only a minority had DOE (38.6% and 45.5%), CB (23.3% and 15.9%), and wheezing (24.4% and 19.1%), yielding a positive predictive value (PPV) of only 53% for any respiratory symptom in the setting of any spirometric respiratory impairment. In addition, most participants who had DOE (73.0%), CB (67.8%), and wheezing (66.8%) did not have airflow obstruction or restrictive pattern, yielding a PPV of only 26% for any spirometric respiratory impairment in the setting of any respiratory symptom. The results differed only modestly when stratified according to age (40-64 vs 65-80).
conclusionGLI-defined spirometric respiratory impairment increased the likelihood of respiratory symptoms but was nonetheless a poor predictor of respiratory symptoms. Similarly, respiratory symptoms were poor predictors of GLI-defined spirometric respiratory impairment. Hence, a comprehensive assessment is needed when evaluating respiratory symptoms, even in the presence of spirometric respiratory impairment.
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