Evidence map›Paper›PMID 25643669›Full record

SynthesisBMC research notes2015

Vitamin D supplementation in children with asthma: a systematic review and meta-analysis.

Munes M Fares, Lina H Alkhaled, Salman M Mroueh, Elie A Akl

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02571660 (Efficacy of Vitamin D on the Clinical Management of Pediatric Patients With Asthma in the Hospital General Naval de Alta Especialidad), which is not on this map. Cited by 22 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 9 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02571660 phase3unknown statusnot on this map

Efficacy of Vitamin D on the Clinical Management of Pediatric Patients With Asthma in the Hospital General Naval de Alta Especialidad

TypeinterventionalSponsorHospital General Naval de Alta Especialidad - Escuela Medico NavalRan2015 to 2017Enrolled100ConditionsAsthmaArmsGINA treatment fot asthma +vit.D low supplementation dose, GINA treatment fot asthma +vit.D high supplementation dose
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 9 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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  4. Vitamin D for the management of asthma.The Cochrane database of systematic reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Munes M FaresDepartment of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon. fares.munes@gmail.com.
Lina H AlkhaledDepartment of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon. lina.alkhaled@hotmail.com.
Salman M MrouehDepartment of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon. smroueh@aub.edu.lb.
Elie A AklDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon. ea32@aub.edu.lb.
American University of Beirut · LBAmerican University of Beirut Medical Center · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiologic studies suggest an association between vitamin D deficiency and atopic diseases, including asthma. The objective of this study was to systematically review the benefits and harms of vitamin D supplementation in children with asthma.

methodsWe used standard Cochrane systematic review methodology. The search strategy included an electronic search in February 2013 of MEDLINE and EMBASE. Two reviewers completed in duplicate and independently study selection, data abstraction, and assessment of risk of bias. We pooled the results of trials using a random-effects model. We assessed the quality of evidence by outcome using the GRADE methodology.

resultsFour trials with a total of 149 children met eligibility criteria. The trials had major methodological limitations. Given the four studies reporting on asthma symptoms used different instruments to measure that outcome, we opted not to conduct a meta-analysis. Three of those studies reported improvement in asthma symptoms in the vitamin D supplemented group study, while the fourth reported no effect (very low quality evidence). For the lung function outcome, a meta-analysis of two trials assessing post treatment FEV-1 found a mean difference of 0.54 liters per second (95% CI -5.28; 4.19; low quality evidence). For the vitamin D level outcome, a meta-analysis of three trials found a mean difference of 6.56 ng/ml (95% CI -0.64; 13.77; very low quality evidence).

conclusionsThe available very low to low quality evidence does not confirm or rule out beneficial effects of vitamin D supplementation in children with asthma. Large-scale, well-designed and executed randomized controlled trials are needed to better understand the effectiveness and safety of vitamin D in children with asthma.

Indexed as

Dietary SupplementsAdolescentAsthmaChildClinical Trials as TopicFemaleHumansMaleRespiratory Function TestsVitamin DVitamin D DeficiencyVitamin D

Identifiers

PMID25643669
PMCPMC4328422
OpenAlexW2066251302

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.