ArticleeLife2015
Independent theta phase coding accounts for CA1 population sequences and enables flexible remapping.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Hippocampal Place Cells with NMDARs Do Not Require Excitation and Inhibition to Be Reciprocally Tuned.bioRxiv : the preprint server for biology · 2026Article
- Deciphering hippocampal place codes in weak theta rhythms.Nature communications · 2026Article
- Embedding stochastic dynamics of the environment in spontaneous activity by prediction-based plasticity.eLife · 2025Article
- Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations.bioRxiv : the preprint server for biology · 2025Article
- Action of GABAThe journal of physiological sciences : JPS · 2024Article
- Phase information is conserved in sparse, synchronous population-rate-codes via phase-to-rate recoding.Nature communications · 2023Article
- Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics.The Journal of physiology · 2023Article
- Learning to predict future locations with internally generated theta sequences.PLoS computational biology · 2023Article
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- Decoding cognition from spontaneous neural activity.Nature reviews. Neuroscience · 2022Review
- Rhythms of human attention and memory: An embedded process perspective.Frontiers in human neuroscience · 2022Review
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- Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Advantages and detection of phase coding in the absence of rhythmicity.Hippocampus · 2020Article
- Impact of functional synapse clusters on neuronal response selectivity.Nature communications · 2020Article
- The role of replay and theta sequences in mediating hippocampal-prefrontal interactions for memory and cognition.Hippocampus · 2020Review
- An Attempt at a Unified Theory of the Neocortical Microcircuit in Sensory Cortex.Frontiers in neural circuits · 2020Article
- Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex.Nature communications · 2019Article
- Hippocampal Sequences During Exploration: Mechanisms and Functions.Frontiers in cellular neuroscience · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hippocampal place cells encode an animal's past, current, and future location through sequences of action potentials generated within each cycle of the network theta rhythm. These sequential representations have been suggested to result from temporally coordinated synaptic interactions within and between cell assemblies. Instead, we find through simulations and analysis of experimental data that rate and phase coding in independent neurons is sufficient to explain the organization of CA1 population activity during theta states. We show that CA1 population activity can be described as an evolving traveling wave that exhibits phase coding, rate coding, spike sequences and that generates an emergent population theta rhythm. We identify measures of global remapping and intracellular theta dynamics as critical for distinguishing mechanisms for pacemaking and coordination of sequential population activity. Our analysis suggests that, unlike synaptically coupled assemblies, independent neurons flexibly generate sequential population activity within the duration of a single theta cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.