ArticleNature neuroscience2015
Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Response Flexibility: The Role of the Lateral Habenula.Frontiers in behavioral neuroscience · 2022Pooled it
- Mesohabenular glutamatergic regulation of the consequences of uncontrollable stress.bioRxiv : the preprint server for biology · 2026Article
- Non-response to short-term ketamine use for treatment-resistant depression.Pharmacological reports : PR · 2025Observational
- Functional Adaptation in the Brain Habenulo-Mesencephalic Pathway During Cannabinoid Withdrawal.Cells · 2024Article
- A discrete subpopulation of PFC-LHb neurons govern cocaine place preference.Translational psychiatry · 2024Article
- AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula.Communications biology · 2024Article
- Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system.Translational psychiatry · 2024Article
- Prefrontal-habenular microstructural impairments in human cocaine and heroin addiction.Neuron · 2022Article
- Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects.Molecular psychiatry · 2022Article
- Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats.Addiction biology · 2022Article
- Calcium-permeable AMPA receptor activity and GluA1 trafficking in the basolateral amygdala regulate operant alcohol self-administration.Addiction biology · 2021Article
- Therapeutic Potentials of Ketamine and Esketamine in Obsessive-Compulsive Disorder (OCD), Substance Use Disorders (SUD) and Eating Disorders (ED): A Review of the Current Literature.Brain sciences · 2021Article
- Synaptic Adaptations at the Rostromedial Tegmental Nucleus Underlie Individual Differences in Cocaine Avoidance Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Endocannabinoid and dopaminergic system: the pas de deux underlying human motivation and behaviors.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Lateral habenula dysfunctions in Tm4sf2Neurobiology of disease · 2021Article
- Output-Specific Adaptation of Habenula-Midbrain Excitatory Synapses During Cocaine Withdrawal.Frontiers in synaptic neuroscience · 2021Article
- Stress induces divergent gene expression among lateral habenula efferent pathways.Neurobiology of stress · 2020Article
- NMDA receptor-dependent long-term depression in the lateral habenula: implications in physiology and depression.Scientific reports · 2020Article
- Circuits and functions of the lateral habenula in health and in disease.Nature reviews. Neuroscience · 2020Review
- From controlled to compulsive drug-taking: The role of the habenula in addiction.Neuroscience and biobehavioral reviews · 2019Review
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.