ArticlePLoS genetics2015
The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovary.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Article
- Regulation of somatic stem cell and niche precursor fates and proliferation of by Wnt, JAK-STAT, Hedgehog and Hippo/Yorkie pathways during Drosophila pupal ovary development resembles the signaling framework organizing adult stem cell behavior.bioRxiv : the preprint server for biology · 2025Article
- Chinmo is a novel regulator of differential Hippo signaling response within a single developing organ.bioRxiv : the preprint server for biology · 2025Article
- Bio-characteristics, tissue expression of miR-375 in hypothalamic-pituitary-ovarian axis and its regulation in reproduction-related diseases.Scientific reports · 2024Article
- Gene Protein Sequence Evolution Can Predict the Rapid Divergence of Ovariole Numbers in the Drosophila melanogaster Subgroup.Genome biology and evolution · 2024Article
- Niche formation and function in developing tissue: studies from the Drosophila ovary.Cell communication and signaling : CCS · 2023Review
- Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease.Endocrine reviews · 2022Review
- A dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis.Cell death & disease · 2022Article
- Characterization of reproductive proteins in the Mexican fruit fly points towards the evolution of novel functions.Proceedings. Biological sciences · 2022Article
- Transcription Analysis for Core Networks of lncRNAs-mRNAs: Implication for Potential Role in Sterility ofBiology · 2022Article
- Distinct gene expression dynamics in germ line and somatic tissue during ovariole morphogenesis in Drosophila melanogaster.G3 (Bethesda, Md.) · 2022Article
- Distant activation of Notch signaling induces stem cell niche assembly.PLoS genetics · 2021Article
- Article
- Article
- Molecular control of the female germline stem cell niche size in Drosophila.Cellular and molecular life sciences : CMLS · 2019Review
- Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Drosophila anion exchanger 2 is required for proper ovary development and oogenesis.Developmental biology · 2019Article
- Reproductive Capacity Evolves in Response to Ecology through Common Changes in Cell Number in Hawaiian Drosophila.Current biology : CB · 2019Article
- Live imaging reveals hub cell assembly and compaction dynamics during morphogenesis of the Drosophila testis niche.Developmental biology · 2019Article
- Heterogeneity of primordial germ cells.Current topics in developmental biology · 2019Review
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2 authors.
Funding
Abstract
The Hippo pathway regulates organ size, stem cell proliferation and tumorigenesis in adult organs. Whether the Hippo pathway influences establishment of stem cell niche size to accommodate changes in organ size, however, has received little attention. Here, we ask whether Hippo signaling influences the number of stem cell niches that are established during development of the Drosophila larval ovary, and whether it interacts with the same or different effector signaling pathways in different cell types. We demonstrate that canonical Hippo signaling regulates autonomous proliferation of the soma, while a novel hippo-independent activity of Yorkie regulates autonomous proliferation of the germ line. Moreover, we demonstrate that Hippo signaling mediates non-autonomous proliferation signals between germ cells and somatic cells, and contributes to maintaining the correct proportion of these niche precursors. Finally, we show that the Hippo pathway interacts with different growth pathways in distinct somatic cell types, and interacts with EGFR and JAK/STAT pathways to regulate non-autonomous proliferation of germ cells. We thus provide evidence for novel roles of the Hippo pathway in establishing the precise balance of soma and germ line, the appropriate number of stem cell niches, and ultimately regulating adult female reproductive capacity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.