ArticleJournal of abnormal psychology2015
Enhanced error-related brain activity in children predicts the onset of anxiety disorders between the ages of 6 and 9.
Article in Journal of abnormal psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Event-related potential in juvenile obsessive-compulsive disorder: a systematic review and meta-analysis of error- and correct-related negativity.European child & adolescent psychiatry · 2025Pooled it
- Non-invasive brain stimulation modulates neural correlates of performance monitoring in patients with obsessive-compulsive disorder.NeuroImage. Clinical · 2022Trial
- Error-related brain activity in pediatric anxiety disorders remains elevated following individual therapy: a randomized clinical trial.Journal of child psychology and psychiatry, and allied disciplines · 2018Trial
- Attention bias modification reduces neural correlates of response monitoring.Biological psychology · 2017Trial
- Exploring Longitudinal Associations Among Error-Related Negativity, Perception of Interpersonal Events, and Internalizing Symptoms in Female Adolescents.Research on child and adolescent psychopathology · 2026Article
- Family Engagement in a Digital Intervention Targeting Risk for Anxiety in Parent-Child Dyads: Mixed Methods Study.JMIR pediatrics and parenting · 2026Article
- Translating neurophysiological biomarkers into clinical tools: A psychometric blueprint illustrated with the error-related negativity.The American psychologist · 2025Review
- Integrating Multimodal Neuroimaging of Error Monitoring to Estimate Future Anxiety in Adolescents.JAMA network open · 2025Article
- Threats That Arise From Within: Changes in Error Processing and the Prospective Prediction of Everyday Avoidance.Biological psychiatry global open science · 2025Article
- Emotion Regulation Moderates the Prospective Association between ERN and Anxiety in Early Adolescence: An Age-Specific Moderation of Cognitive Reappraisal but not Expressive Suppression.Research on child and adolescent psychopathology · 2025Article
- Perceived acceptability and appropriateness of a web-based program targeting risk for anxiety in young children and their parents.Journal of pediatric psychology · 2025Article
- Anxiety Symptoms in Young Children Are Associated With a Maladaptive Neurobehavioral Profile of Error Responding.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Multiple Adaptive Attention-Bias-Modification Programs to Alter Normative Increase in the Error-Related Negativity in Adolescents.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
- The associations among sleep-related difficulties, anxiety, and error-related brain activity in youth.Biological psychology · 2024Article
- Associations between error-related negativity and childhood anxiety risk differ based on socioeconomic status.Developmental psychology · 2023Article
- The gray matter morphology associated with the electrophysiological response to errors in individuals with high trait anxiety.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- A biomarker discovery framework for childhood anxiety.Frontiers in psychiatry · 2023Article
- Translating Big Data to Clinical Outcomes in Anxiety: Potential for Multimodal Integration.Current psychiatry reports · 2022Review
- The role of attentional shifting in the relation between error monitoring and anxiety in youth.Psychiatry research. Neuroimaging · 2022Article
- Associations between lifetime stress exposure and the error-related negativity (ERN) differ based on stressor characteristics and exposure timing in young adults.Cognitive, affective & behavioral neuroscience · 2022Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Considering that anxiety disorders frequently begin before adulthood and often result in chronic impairment, it is important to characterize the developmental pathways leading to the onset of clinical anxiety. Identifying neural biomarkers that can predict the onset of anxiety in childhood may increase our understanding of the etiopathogenesis of anxiety, as well as inform intervention and prevention strategies. An event-related potential (ERP), the error-related negativity (ERN), has been proposed as a biomarker of risk for anxiety and has previously been associated with anxiety in both adults and children. However, no previous study has examined whether the ERN can predict the onset of anxiety disorders. In the current study, ERPs were recorded while 236 healthy children, approximately 6 years of age, performed a go/no-go task to measure the ERN. Three years later, children and parents came back to the lab and completed diagnostic interviews regarding anxiety disorder status. Results indicated that enhanced error-related brain activity at age 6 predicted the onset of new anxiety disorders by age 9, even when controlling for baseline anxiety symptoms and maternal history of anxiety. Considering the potential utility of identifying early biomarkers of risk, this is a novel and important extension of previous work.
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