Evidence map›Paper›PMID 25643081›Full record

ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2015

Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study.

Chen-Wei Wei, Thu-Mai Nguyen, Jinjun Xia, Bastien Arnal, Emily Y Wong, Ivan M Pelivanov, Matthew O'Donnell

Abstract read
In one paragraph

Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Vibroacoustic signatures: proof of concept for simple material characterization during needle interventions.International journal of computer assisted radiology and surgery · 2025
    Article
  5. Review
  6. Review of Deep Learning Approaches for Interleaved Photoacoustic and Ultrasound (PAUS) Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chen-Wei Wei
Thu-Mai Nguyen
Jinjun Xia
Bastien Arnal
Emily Y Wong
Ivan M Pelivanov
Matthew O'Donnell

Funding

Nano-agent for photoacoustic theranostics of dialysis graft/fistula occlusionsR01HL125339 · NHLBI · UNIVERSITY OF WASHINGTON · PI POZZO, LILO D. · 2015 to 2019
$2.8M
Sensitive tumor detection with magnetomotive imagingR01CA170734 · NCI · UNIVERSITY OF WASHINGTON · PI GAO, XIAOHU · 2012 to 2015
$1.8M
Non-invasive trapping and imaging of circulating tumor cells in the peripheral vaR01EB016034 · NIBIB · UNIVERSITY OF WASHINGTON · PI O'DONNELL, MATTHEW · 2013 to 2016
$1.7M
Sensitive and multiplexed analysis of cancer biomarkers with QD barcodesR01CA131797 · NCI · UNIVERSITY OF WASHINGTON · PI GAO, XIAOHU · 2008 to 2012
$1.6M
Nanotechnology and Physical Science Training Program in Cancer ResearchT32CA138312 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2009 to 2013
$1.5M
Targeted and traceable delivery of siRNA with nanoparticle-amphipolR01CA140295 · NCI · UNIVERSITY OF WASHINGTON · PI GAO, XIAOHU · 2009 to 2010
$647k
NCI NIH HHS R01 CA131797NCI NIH HHS R01CA131797NCI NIH HHS R01 CA140295NCI NIH HHS R01CA140295NCI NIH HHS R01 CA170734NCI NIH HHS R01CA170734NCI NIH HHS T32 CA138312NCI NIH HHS T32CA138312NHLBI NIH HHS R01 HL125339NIBIB NIH HHS R01 EB016034NIBIB NIH HHS R0 1EB016034
6 · The paper itself

Abstract

Because of depth-dependent light attenuation, bulky, low-repetition-rate lasers are usually used in most photoacoustic (PA) systems to provide sufficient pulse energies to image at depth within the body. However, integrating these lasers with real-time clinical ultrasound (US) scanners has been problematic because of their size and cost. In this paper, an integrated PA/US (PAUS) imaging system is presented operating at frame rates >30 Hz. By employing a portable, low-cost, low-pulse-energy (~2 mJ/pulse), high-repetition-rate (~1 kHz), 1053-nm laser, and a rotating galvo-mirror system enabling rapid laser beam scanning over the imaging area, the approach is demonstrated for potential applications requiring a few centimeters of penetration. In particular, we demonstrate here real-time (30 Hz frame rate) imaging (by combining multiple single-shot sub-images covering the scan region) of an 18-gauge needle inserted into a piece of chicken breast with subsequent delivery of an absorptive agent at more than 1-cm depth to mimic PAUS guidance of an interventional procedure. A signal-to-noise ratio of more than 35 dB is obtained for the needle in an imaging area 2.8 × 2.8 cm (depth × lateral). Higher frame rate operation is envisioned with an optimized scanning scheme.

Indexed as

AnimalsChickensHumansMuscle, SkeletalPhantoms, ImagingPhotoacoustic TechniquesUltrasonography, Interventional

Identifiers

PMID25643081
PMCPMC4610852

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.