Evidence map›Paper›PMID 25642839›Full record

ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2015

Latent class profiles of internalizing and externalizing psychosocial health indicators are differentially associated with sexual transmission risk: Findings from the CFAR network of integrated clinical systems (CNICS) cohort study of HIV-infected men engaged in primary care in the United States.

Matthew J Mimiaga, Katie Biello, Sari L Reisner, Heidi M Crane, Johannes Wilson, Chris Grasso, Mari M Kitahata, Wm Christopher Mathews, Kenneth H Mayer, Steven A Safren

Open access · greenAbstract read
In one paragraph

Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Psychosocial Distress Among Young Men Who Have Sex With Men: A Scoping Review.Journal of psychosocial nursing and mental health services · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Matthew J MimiagaHarvard Medical School/Massachusetts General Hospital.
Katie BielloHarvard School of Public Health.
Sari L ReisnerHarvard School of Public Health.
Heidi M CraneUniversity of Washington School of Medicine.
Johannes WilsonFenway Health.
Chris GrassoFenway Health.
Mari M KitahataUniversity of Washington School of Medicine.
Wm Christopher MathewsUniversity of California San Diego.
Kenneth H MayerFenway Health.
Steven A SafrenHarvard Medical School/Massachusetts General Hospital.
Harvard University · USFenway Health · USUniversity of Washington · USUniversity of California, San Diego · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Judith Tsui · 1988 to 2026
$104.9M
Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Patient reported outcomes in routine clinical care of patients infected with HIVU01AR057954 · NIAMS · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M., CRANE, PAUL K · 2009 to 2013
$7.8M
3/4 Alcohol Research Consortium in HIV - Epidemiological Research Arm (ARCH-ERA)U01AA020793 · NIAAA · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M., LAU, BRYAN · 2011 to 2020
$5.8M
Optimal assessment of HAART adherence in routine clinical careR01MH084759 · NIMH · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M. · 2008 to 2012
$2.9M
Addressing psychosocial comorbidities in HIV treatment and preventionK24MH094214 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2011 to 2015
$858k
Behavioral Activation and HIV Risk Reduction for MSM with Crystal Meth AbuseR34DA031028 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI MIMIAGA, MATTHEW JAMES · 2011 to 2013
$736k
NIAAA NIH HHS U01 AA020793NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI050410NIAID NIH HHS R24 AI067039NIAID NIH HHS R24AI067039NIAMS NIH HHS U01 AR057954NIAMS NIH HHS U01AR057954NIDA NIH HHS R34 DA031028NIDA NIH HHS R34DA031028NIMH NIH HHS K24 MH094214NIMH NIH HHS K24MH094214NIMH NIH HHS R01 MH084759
6 · The paper itself

Abstract

objectiveTo examine whether latent class indicators of negative affect and substance use emerged as distinct psychosocial risk profiles among HIV-infected men, and if these latent classes were associated with high-risk sexual behaviors that may transmit HIV.

methodsData were from HIV-infected men who reported having anal intercourse in the past 6 months and received routine clinical care at 4 U.S. sites in the Centers for AIDS Research Network of Integrated Clinical Systems cohort (n = 1,210). Latent class membership was estimated using binary indicators for anxiety, depression, alcohol and/or drug use during sex, and polydrug use. Generalized estimating equations modeled whether latent class membership was associated with HIV sexual transmission risk in the past 6 months.

resultsThree latent classes of psychosocial indicators emerged: (a) internalizing (15.3%; high probability of anxiety and major depression); (b) externalizing (17.8%; high probability of alcohol and/or drug use during sex and polydrug use); (c) low psychosocial distress (67.0%; low probability of all psychosocial factors examined). Internalizing and externalizing latent class membership were associated with HIV sexual transmission risk, compared to low psychosocial class membership; externalizing class membership was also associated with higher sexual transmission risk compared to internalizing class membership.

conclusionsDistinct patterns of psychosocial health characterize this sexually active HIV-infected male patient population and are strongly associated with HIV sexual transmission risk. Public Health intervention efforts targeting HIV sexual risk transmission may benefit from considering symptom clusters that share internalizing or externalizing properties.

Indexed as

Health BehaviorAdultCohort StudiesHIV InfectionsHumansMalePrimary Health CareRisk FactorsRisk-TakingSexually Transmitted DiseasesSubstance-Related DisordersUnited StatesYoung Adult

Identifiers

PMID25642839
PMCPMC4522398
OpenAlexW2078810665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.