Evidence map›Paper›PMID 25642761›Full record

ArticleBone marrow transplantation2015

Hematopoietic SCT in Europe 2013: recent trends in the use of alternative donors showing more haploidentical donors but fewer cord blood transplants.

J R Passweg, H Baldomero, P Bader, C Bonini, S Cesaro, P Dreger, R F Duarte, C Dufour, J H F Falkenburg, D Farge-Bancel and 7 more

Registry-linked trialOpen access · hybridAbstract readMulticenter Study
In one paragraph

Article in Bone marrow transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03821519 (Phase I/II Trial of Donor Derived Cytokine Induced Killer), which is not on this map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
29.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03821519 phase1 / phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

Phase I/II Trial of Donor Derived Cytokine Induced Killer (CIK) Cells Infusion for Relapsed Hematologic Malignancy After Haploidentical Stem Cell Transplantation

TypeinterventionalSponsorA.O. Ospedale Papa Giovanni XXIIIRan2019 to 2023Enrolled20ConditionsRelapsed Hematologic MalignancyArmsdonor-derived CIK cells
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 203 citations in OpenAlex.

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  20. The SARS-Cov-2 Pandemic: A Good Time for Stem Cell Transplantation?Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 9 countries.

J R PasswegEBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
H BaldomeroEBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
P BaderUniversitätsklinikum Frankfurt, Goethe-Universität, Frankfurt am Main, Germany.
C BoniniOspedale San Raffaele, Milan, Italy.
S CesaroPaediatric Haematology Oncology, Policlinico G.B. Rossi, Verona, Italy.
P DregerMedizinische Klinik V, University of Heidelberg, Heidelberg, Germany.
R F DuarteHospital Duran i Reynals, Barcelona, Spain.
C DufourInstitute G. Gaslini, Genova, Italy.
J H F FalkenburgDepartment of Hematology, University Medical Center, Leiden, The Netherlands.
D Farge-BancelService de Médecine Interne, Hopital St Louis, Paris, France.
A GenneryInstitute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK.
N KrögerUniversity Hospital Eppendorf, Hamburg, Germany.
F LanzaHematology and BMT Unit, Cremona, Italy.
A NaglerChaim Sheba Medical Center, Tel-Hashomer, Israel.
A SuredaHospital Duran i Reynals, Barcelona, Spain.
M MohtyHospital Saint Antoine, Paris, France.
European Society for Blood and Marrow Transplantation (EBMT)
Goethe University Frankfurt · DEHeidelberg University · DESheba Medical Center · ILSorbonne Université · FRUniversität Hamburg · DEUniversity of Basel · CHHôpital Saint-Louis · FRIRCCS Ospedale San Raffaele · ITIstituto Giannina Gaslini · ITLeiden University · NLUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A record number of 39,209 HSCT in 34,809 patients (14,950 allogeneic (43%) and 19,859 autologous (57%)) were reported by 658 centers in 48 countries to the 2013 survey. Trends include: more growth in allogeneic than in autologous HSCT, increasing use of sibling and unrelated donors and a pronounced increase in haploidentical family donors when compared with cord blood donors for those patients without a matched related or unrelated donor. Main indications were leukemias, 11,190 (32%; 96% allogeneic); lymphoid neoplasias, 19,958 (57%; 11% allogeneic); solid tumors, 1543 (4%; 4% allogeneic); and nonmalignant disorders, 1975 (6%; 91% allogeneic). In patients without a matched sibling or unrelated donor, alternative donors are used. Since 2010 there has been a marked increase of 96% in the number of transplants performed from haploidentical relatives (802 in 2010 to 1571 in 2013), whereas the number of unrelated cord blood transplants has slightly decreased (789 in 2010 to 666 in 2013). The use of donor type varies greatly throughout Europe.

Indexed as

Cord Blood Stem Cell TransplantationDatabases, FactualHematopoietic Stem Cell TransplantationUnrelated DonorsAllograftsAutograftsEuropeFemaleHumansMaleNeoplasms

Identifiers

PMID25642761
PMCPMC4387247
OpenAlexW2069968835

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.