ArticleCurrent opinion in psychology2015
Integrating NIMH Research Domain Criteria (RDoC) into Depression Research.
Article in Current opinion in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Developing a translational research framework for MDD: combining biomolecular mechanisms with a spiraling risk factor model.Frontiers in psychiatry · 2024Pooled it
- Subcortical shape alterations in major depressive disorder: Findings from the ENIGMA major depressive disorder working group.Human brain mapping · 2022Pooled it
- The Transdiagnostic Origins of Anxiety and Depression During the Pediatric Period: Linking NIMH Research Domain Criteria (RDoC) Constructs to Ecological Systems.Development and psychopathology · 2021Pooled it
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Applying new RDoC dimensions to the development of emotion regulation: Examining the influence of maternal emotion regulation on within-individual change in child emotion regulation.Development and psychopathology · 2021Trial
- The Research Domain Criteria (RDoC) and Youth Depression - In Context.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026Article
- Decoding causal m6A: a bioinformatics roadmap for psychiatric disorders.Briefings in bioinformatics · 2026Review
- Shared neurogenetic architecture links adolescent neurodevelopmental deviations to adult psychopathological procrastination.Molecular psychiatry · 2026Article
- The most important features in generalized additive models might be groups of features.Scientific reports · 2026Article
- Artificial Intelligence-Based Depression Detection.Sensors (Basel, Switzerland) · 2026Article
- Psychological and somatic distress profiles in young adults in and out of conflict settings: a cluster-based analysis of three population-based studies in Ukraine and Switzerland.Frontiers in public health · 2026Observational
- State-dependent modulation of brain co-activation patterns induced by individually targeted VLPFC stimulation during viewing emotional film clips.Frontiers in human neuroscience · 2026Article
- Ceramides and neuroinflammation as immunometabolic drivers and biomarkers of major depressive disorder, treatment-resistant depression, and suicidal vulnerability.Frontiers in pharmacology · 2026Review
- Parsing Clinical and Neurobiological Sources of Heterogeneity in Depression.Biological psychiatry · 2025Article
- TRPC4/5 inhibitors: Phase I results and proof of concept studies.European archives of psychiatry and clinical neuroscience · 2025Review
- Why is rumination unhelpful in adolescents? Two studies examining the causal role of abstract processing.Journal of affective disorders · 2025Article
- Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders.Neuroscience · 2025Review
- Perseverative cognitions, negative valence systems, positive valence systems, social disconnection, and suicide: testing a mediator model among university students.BMC psychology · 2025Article
- The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach.BMC psychiatry · 2025Article
- Cultural adaptation of the facial emotion perception test for use in Zimbabwe: A pilot study.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The NIMH Research Domain Criteria (RDoC) initiative grew out of the agency's goal to develop "new ways of classifying mental disorders based on behavioral dimensions and neurobiological measures" (NIMH, 2008). In this article, we review how depression research can be meaningfully conducted within an RDoC framework, with a particular focus on the negative valence systems construct of Loss. New efforts to understand depression within the context of RDoC must seek an integrative understanding of the disorder across multiple units of analysis from genes to neural circuits to behavior. In addition, the constructs or processes must be understood within the context of specific environmental and developmental influences. Key concepts are discussed and we end by highlighting research on rumination as a prime example of research that is consistent with RDoC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.