ArticleJournal of diabetes research2015
Suppressive effect of insulin on the gene expression and plasma concentrations of mediators of asthmatic inflammation.
Article in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Pioglitazone prevents obesity-related airway hyperreactivity and neuronal MAmerican journal of physiology. Lung cellular and molecular physiology · 2021Article
- Insulin acutely increases agonist-induced airway smooth muscle contraction in humans and rats.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Bariatric Surgery: Remission of Inflammation, Cardiometabolic Benefits, and Common Adverse Effects.Journal of the Endocrine Society · 2020Review
- Hypertension and diabetes mellitus as risk factors for asthma in Korean adults: the Sixth Korea National Health and Nutrition Examination Survey.International health · 2020Article
- Obesity and Asthma: A Missing Link.International journal of molecular sciences · 2017Review
- Macronutrient intake, insulin secretion, oxidative stress & inflammation: Clinico-pathological implications.The Indian journal of medical research · 2016Article
- Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms.Mediators of inflammation · 2016Review
- Chronic Comorbidities Contribute to the Burden and Costs of Persistent Asthma.Mediators of inflammation · 2015Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
background and hypothesisFollowing our recent demonstration that the chronic inflammatory and insulin resistant state of obesity is associated with an increase in the expression of mediators known to contribute to the pathogenesis of asthma and that weight loss after gastric bypass surgery results in the reduction of these genes, we have now hypothesized that insulin suppresses the cellular expression and plasma concentrations of these mediators.
methodsThe expression of IL-4, LIGHT, LTBR, ADAM-33, and TSLP in MNC and plasma concentrations of LIGHT, TGF-β1, MMP-9, MCP-1, TSLP, and NOM in obese patients with T2DM were measured before, during, and after the infusion of a low dose (2 U/h) infusion of insulin for 4 hours. The patients were also infused with dextrose or saline for 4 hours on two separate visits and served as controls. Results. Following insulin infusion, the mRNA expression of IL-4, ADAM-33, LIGHT, and LTBR mRNA expression fell significantly (P < 0.05 for all). There was also a concomitant reduction in plasma NOM, LIGHT, TGF-β1, MCP-1, and MMP-9 concentrations.
conclusionsInsulin suppresses the expression of these genes and mediators related to asthma and may, therefore, have a potential role in the treatment of asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.