ArticleBrain and behavior2015
Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus.
Article in Brain and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 88 citations in OpenAlex.
- Metabolic Syndrome and Psychological Effects of Exercise in Hemodialysis Patients.International journal of environmental research and public health · 2021Trial
- The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety.Scientific reports · 2021Trial
- Obesity and Depression.Advances in experimental medicine and biology · 2026Review
- Betel-quid Use Is Associated with Depression.International journal of medical sciences · 2026Article
- Exploring the Association between Health Literacy and Diabetes Risk in Adults: Insights from a Pilot Study in Leiria.Portuguese journal of public health · 2025Article
- Association between changes in obesity status and neuropsychiatric health and brain structure in different glucose status.Frontiers in nutrition · 2025Article
- Adherence to Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay Diet in Relation to Serum Brain-Derived Neurotrophic Factor Concentrations and Metabolic Health Status in Adults.Current developments in nutrition · 2024Article
- The interactive effects of psychosocial stress and diet composition on health in primates.Neuroscience and biobehavioral reviews · 2023Review
- Rosiglitazone Mitigates Dexamethasone-Induced Depression in Mice via Modulating Brain Glucose Metabolism and AMPK/mTOR Signaling Pathway.Biomedicines · 2023Article
- Association between anxiety and metabolic syndrome: An updated systematic review and meta-analysis.Frontiers in psychiatry · 2023Review
- Higher metabolic variability increases the risk of depressive disorder in type 2 diabetes mellitus: a longitudinal nationwide cohort study.Frontiers in psychiatry · 2023Article
- Investigating the associations between childhood trauma and cardiovascular health in midlife.Journal of traumatic stress · 2022Article
- Review
- Understanding Historical Trauma Among Urban Indigenous Adults at Risk for Diabetes.American Indian and Alaska native mental health research (Online) · 2022Article
- Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons.Molecular psychiatry · 2021Article
- The relationship between depression and risk of metabolic syndrome: a meta-analysis of observational studies.Clinical diabetes and endocrinology · 2021Article
- High Fructose Diet Induces Sex-specific Modifications in Synaptic Respiration and Affective-like Behaviors in Rats.Neuroscience · 2021Article
- Role of glucocorticoid receptor phosphorylation-mediated synaptic plasticity in anxiogenic and depressive behaviors induced by monosodium glutamate.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- The impact of metabolic syndrome on mental health-related quality of life and depressive symptoms.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Interactive association of sleep duration and sleep quality with the prevalence of metabolic syndrome in adult Chinese males.Experimental and therapeutic medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression.
methodsWe evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV.
resultsOf 260 consecutively screened subjects, 150 (56.9±8.1 years old, males=56.7%, BMI=27.2±4.1 kg/m2) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P<0.001) and lifetime major depression (P<0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity.
conclusionsOur data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.