ArticleBrain and behavior2015
Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring.
Article in Brain and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 94 citations in OpenAlex.
- ILAE dietary treatments task force special report: Maternal ketogenic diet exposure in epilepsy pregnancy registries-A call to action.Epilepsia open · 2026Article
- Maternal Nutrition During Pregnancy and Fetal Outcome, Short- and Long-Term Health Effects: A Narrative Review.Nutrients · 2026Review
- Ketogenic Diet Modulates Cerebellar AQP4 in an Age-dependent Manner and Parallels Reduced Anxiety-like Behavior in Rats.Cerebellum (London, England) · 2026Article
- Dietary restriction as a potential neuroprotective intervention: a narrative review of its impact on neuroinflammation across neurodegenerative diseases and other neurological disorders.Frontiers in nutrition · 2026Review
- Role of the ketogenic diet in neurodevelopmental disorders: neuroprotection and clinical practice.Frontiers in nutrition · 2026Review
- The Role of Various Types of Diets in the Treatments of Depressive Disorders.Medicina (Kaunas, Lithuania) · 2025Review
- Ketogenic diet therapy for epilepsy during pregnancy and lactation: An international survey exploring clinician perspectives.Epilepsia open · 2025Article
- GLUT1 and Cerebral Glucose Hypometabolism in Human Focal Cortical Dysplasia Is Associated with Hypermethylation of Key Glucose Regulatory Genes.Molecular neurobiology · 2025Article
- Nutritional Strategies in Major Depression Disorder: From Ketogenic Diet to Modulation of the Microbiota-Gut-Brain Axis.Molecular neurobiology · 2025Review
- Medium-Chain Triglyceride Administration Induces Antidepressant Effects in Animal Models by Increasing Beta-Hydroxybutyrate Levels.Yonago acta medica · 2025Article
- Perspectives on the ketogenic diet as a non-pharmacological intervention for major depressive disorder.Trends in psychiatry and psychotherapy · 2025Review
- Sex-dependent effects of a gestational ketogenic diet on offspring birth and lifespan.PloS one · 2025Article
- KETO-MOOD: Ketogenic Diet for Microbiome Optimization and Overcoming Depression - A Protocol for a Randomized Controlled Trial.Neuroimmunomodulation · 2025Article
- Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3.Nutrients · 2024Review
- Review
- Review
- The Potential Role of the Ketogenic Diet in Serious Mental Illness: Current Evidence, Safety, and Practical Advice.Journal of clinical medicine · 2024Review
- Impact of Maternal Environment and Inflammation on Fetal Neurodevelopment.Antioxidants (Basel, Switzerland) · 2024Review
- Review
- Ketogenic diet and behavior: insights from experimental studies.Frontiers in nutrition · 2024Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe ketogenic diet (KD) has seen an increase in popularity for clinical and non-clinical purposes, leading to rise in concern about the diet's impact on following generations. The KD is known to have a neurological effect, suggesting that exposure to it during prenatal brain development may alter neuro-anatomy. Studies have also indicated that the KD has an anti-depressant effect on the consumer. However, it is unclear whether any neuro-anatomical and/or behavioral changes would occur in the offspring and persist into adulthood.
methodsTo fill this knowledge gap we assessed the brain morphology and behavior of 8-week-old young-adult CD-1 mice, who were exposed to the KD in utero, and were fed only a standard-diet (SD) in postnatal life. Standardized neuro-behavior tests included the Open-Field, Forced-Swim, and Exercise Wheel tests, and were followed by post-mortem Magnetic Resonance Imaging (MRI) to assess brain anatomy.
resultsThe adult KD offspring exhibit reduced susceptibility to anxiety and depression, and elevated physical activity level when compared with controls exposed to the SD both in utero and postnatally. Many neuro-anatomical differences exist between the KD offspring and controls, including, for example, a cerebellar volumetric enlargement by 4.8%, a hypothalamic reduction by 1.39%, and a corpus callosum reduction by 4.77%, as computed relative to total brain volume.
conclusionsThese results suggest that prenatal exposure to the KD programs the offspring neuro-anatomy and influences their behavior in adulthood.
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