Evidence map›Paper›PMID 25642368›Full record

ArticlePLoS currents2014

Large-sized Fetal Striatal Grafts in Huntington's Disease Do Stop Growing: Long-term Monitoring in the Florence Experience.

Mario Mascalchi, Stefano Diciotti, Marco Paganini, Andrea Bianchi, Andrea Ginestroni, Letizia Lombardini, Berardino Porfirio, Renato Conti, Nicola Di Lorenzo, Gabriella Barbara Vannelli and 1 more

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In one paragraph

Article in PLoS currents, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mario MascalchiQuantitative and Functional Neuroradiology Research Unit, Meyer Children and Careggi Hospitals, Florence, Italy; Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy.
Stefano DiciottiDepartment of Electrical, Electronic, and Information Engineering "Guglielmo Marconi", University of Bologna, Cesena, Italy.
Marco PaganiniNeurology Unit, Careggi Hospital, Florence, Italy.
Andrea Bianchi
Andrea GinestroniNeuroradiology Unit, Careggi Hospital, Florence, Italy.
Letizia LombardiniHematology Unit, Careggi Hospital, Florence, Italy.
Berardino PorfirioDepartment of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy.
Renato ContiUniversity of Florence.
Nicola Di LorenzoDepartment of Surgery and Translational Medicine, University of Florence, Florence, Italy.
Gabriella Barbara VannelliDepartment of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
Pasquale GallinaDepartment of Surgery and Translational Medicine, University of Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development of six large nodules of solid tissue after bilateral human fetal striatal transplantation in four Huntington's disease patients has raised concern about the safety of this experimental therapy in our setting. We investigated by serial MRI-based volumetric analysis the growth behaviour of such grafts. After 33-73 months from transplantation the size of five grafts was stable and one graft showed a mild decrease in size. Signs neither of intracranial hypertension nor of adjuctive focal neurological deficit have ever been observed. This supports long-term safety of the grafting procedure at our Institution.

Identifiers

PMID25642368
PMCPMC4172581

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.