ArticlePersonalized medicine
'Someday it will be the norm': physician perspectives on the utility of genome sequencing for patient care in the MedSeq Project.
Article in Personalized medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The MilSeq Project: Enabling Personalized Medicine Through Exome Sequencing in the U.S. Air Force
Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care
Who cites it
22 citing papers in PubMed.
- How Primary Care Providers Talk to Patients about Genome Sequencing Results: Risk, Rationale, and Recommendation.Journal of general internal medicine · 2018Trial
- Psychiatric polygenic risk scores: Experience, hope for utility, and concerns among child and adolescent psychiatrists.Psychiatry research · 2024Article
- Perceptions of Nigerian medical students regarding their preparedness for precision medicine: a cross-sectional survey in Lagos, Nigeria.BMC medical education · 2023Article
- The Future of Newborn Genomic Testing.Children (Basel, Switzerland) · 2023Review
- Awareness and utilization of genetic testing among Hispanic and Latino adults living in the US: The Hispanic Community Health Study/Study of Latinos.HGG advances · 2023Article
- Workforce Considerations When Building a Precision Medicine Program.Journal of personalized medicine · 2022Article
- May direct-to-consumer genetic testing have an impact on general practitioners' daily practice? a cross-sectional study of patients' intentions towards this approach.BMC family practice · 2021Article
- Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues.Genome medicine · 2021Article
- Germline whole genome sequencing in pediatric oncology in Denmark-Practitioner perspectives.Molecular genetics & genomic medicine · 2020Article
- The implementation of pharmacogenomics into UK general practice: a qualitative study exploring barriers, challenges and opportunities.Journal of community genetics · 2020Article
- What Results Should Be Returned from Opportunistic Screening in Translational Research?Journal of personalized medicine · 2020Article
- Personal genome testing on physicians improves attitudes on pharmacogenomic approaches.PloS one · 2019Article
- Sequencing Newborns: A Call for Nuanced Use of Genomic Technologies.The Hastings Center report · 2018Article
- Patient and provider perspectives on the development of personalized medicine: a mixed-methods approach.Journal of community genetics · 2018Article
- Article
- Lost in translation: returning germline genetic results in genome-scale cancer research.Genome medicine · 2017Article
- Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.American journal of human genetics · 2016Article
- Personal Genome Sequencing in Ostensibly Healthy Individuals and the PeopleSeq Consortium.Journal of personalized medicine · 2016Review
- Medical student preparedness for an era of personalized medicine: findings from one US medical school.Personalized medicine · 2016Article
- Are physicians prepared for whole genome sequencing? a qualitative analysis.Clinical genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
aimTo describe practicing physicians' perceived clinical utility of genome sequencing. MATERIALS &
methodsWe conducted a mixed-methods analysis of data from 18 primary care physicians and cardiologists in a study of the clinical integration of whole-genome sequencing. Physicians underwent brief genomics continuing medical education before completing surveys and semi-structured interviews.
resultsPhysicians described sequencing as currently lacking clinical utility because of its uncertain interpretation and limited impact on clinical decision-making, but they expressed the idea that its clinical integration was inevitable. Potential clinical uses for sequencing included complementing other clinical information, risk stratification, motivating patient behavior change and pharmacogenetics.
conclusionPhysicians given genomics continuing medical education use the language of both evidence-based and personalized medicine in describing the utility of genome-wide testing in patient care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.