ReviewFrontiers in aging neuroscience2014
Fornix as an imaging marker for episodic memory deficits in healthy aging and in various neurological disorders.
Review in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Identification and validation of supervariants reveal novel loci associated with human white matter microstructure.Genome research · 2024Pooled it
- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter.Nature aging · 2026Article
- Genetically linked brain imaging markers of memory decline in aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Development of a paediatric model of diffuse traumatic brain injury in ferrets.Scientific reports · 2026Article
- Moderating effects of limbic white matter on verbal memory in older adults with multiple sclerosis.Neuropsychology · 2026Article
- Beyond the hippocampus: Limbic white matter injury implicated in post-radiation memory performance in primary brain tumor patients.Neuro-oncology · 2025Article
- Cross-Sectional and Longitudinal Associations Between Olfaction and White-Matter Integrity Across the Lifespan.Human brain mapping · 2025Article
- The cellular associates of late life changes in white matter microstructure.bioRxiv : the preprint server for biology · 2025Article
- Article
- Music training and language learning improve verbal memory performance but do not change white matter characteristics of the splenium: a longitudinal DTI study.Frontiers in psychology · 2025Article
- Free water-corrected fractional anisotropy of the fornix and parahippocampal cingulum predicts longitudinal memory change in cognitively healthy older adults.Neurobiology of aging · 2024Article
- A worldwide study of white matter microstructural alterations in people living with Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Article
- Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants.Neurobiology of aging · 2024Article
- Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making.Aging brain · 2024Article
- A deep neural network estimation of brain age is sensitive to cognitive impairment and decline.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2024Article
- Functional alterations in bipartite network of white and grey matters during aging.NeuroImage · 2023Article
- Multimodal Neuromonitoring and Neurocritical Care in Swine to Enhance Translational Relevance in Brain Trauma Research.Biomedicines · 2023Article
- Overweight/Obesity-related microstructural alterations of the fimbria-fornix in the ABCD study: The role of aerobic physical activity.PloS one · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The fornix is a part of the limbic system and constitutes the major efferent and afferent white matter tracts from the hippocampi. The underdevelopment of or injuries to the fornix are strongly associated with memory deficits. Its role in memory impairments was suggested long ago with cases of surgical forniceal transections. However, recent advances in brain imaging techniques, such as diffusion tensor imaging, have revealed that macrostructural and microstructural abnormalities of the fornix correlated highly with declarative and episodic memory performance. This structure appears to provide a robust and early imaging predictor for memory deficits not only in neurodegenerative and neuroinflammatory diseases, such as Alzheimer's disease and multiple sclerosis, but also in schizophrenia and psychiatric disorders, and during neurodevelopment and "typical" aging. The objective of the manuscript is to present a systematic review regarding published brain imaging research on the fornix, including the development of its tracts, its role in various neurological diseases, and its relationship to neurocognitive performance in human studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.