ArticleFrontiers in neuroanatomy2014
Towards a "canonical" agranular cortical microcircuit.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An MRI-Based, Data-Driven Model of Cortical Laminar Connectivity.Neuroinformatics · 2021Pooled it
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- Shaping dynamical neural computations using spatiotemporal constraints.Biochemical and biophysical research communications · 2024Review
- Multi-scale spiking network model of human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Oscillatory Waveform Shape and Temporal Spike Correlations Differ across Bat Frontal and Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Clustering the cortical laminae: in vivo parcellation.Brain structure & function · 2024Article
- Agranular frontal cortical microcircuit underlying cognitive control in macaques.Frontiers in neural circuits · 2024Review
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- Cortical origin of theta error signals.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Correspondence of functional connectivity gradients across human isocortex, cerebellum, and hippocampus.Communications biology · 2023Article
- Age-related changes in the primary auditory cortex of newborn, adults and aging bottlenose dolphins (Frontiers in neuroanatomy · 2023Article
- Expanding connectomics to the laminar level: A perspective.Network neuroscience (Cambridge, Mass.) · 2023Article
- Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome.Science advances · 2022Article
- Functional architecture of executive control and associated event-related potentials in macaques.Nature communications · 2022Article
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- In vivo measurements of lamination patterns in the human cortex.Human brain mapping · 2022Article
- The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity.Frontiers in neuroanatomy · 2022Article
- NetPyNE Implementation and Scaling of the Potjans-Diesmann Cortical Microcircuit Model.Neural computation · 2021Article
- A Connectomic Hypothesis for the Hominization of the Brain.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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Abstract
Based on regularities in the intrinsic microcircuitry of cortical areas, variants of a "canonical" cortical microcircuit have been proposed and widely adopted, particularly in computational neuroscience and neuroinformatics. However, this circuit is founded on striate cortex, which manifests perhaps the most extreme instance of cortical organization, in terms of a very high density of cells in highly differentiated cortical layers. Most other cortical regions have a less well differentiated architecture, stretching in gradients from the very dense eulaminate primary cortical areas to the other extreme of dysgranular and agranular areas of low density and poor laminar differentiation. It is unlikely for the patterns of inter- and intra-laminar connections to be uniform in spite of strong variations of their structural substrate. This assumption is corroborated by reports of divergence in intrinsic circuitry across the cortex. Consequently, it remains an important goal to define local microcircuits for a variety of cortical types, in particular, agranular cortical regions. As a counterpoint to the striate microcircuit, which may be anchored in an exceptional cytoarchitecture, we here outline a tentative microcircuit for agranular cortex. The circuit is based on a synthesis of the available literature on the local microcircuitry in agranular cortical areas of the rodent brain, investigated by anatomical and electrophysiological approaches. A central observation of these investigations is a weakening of interlaminar inhibition as cortical cytoarchitecture becomes less distinctive. Thus, our study of agranular microcircuitry revealed deviations from the well-known "canonical" microcircuit established for striate cortex, suggesting variations in the intrinsic circuitry across the cortex that may be functionally relevant.
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