ArticleInvertebrate reproduction & development2015
Rotifers as experimental tools for investigating aging.
Article in Invertebrate reproduction & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Reproductive isolation in two strains of the marine rotiferBiodiversity data journal · 2026Article
- Article
- Maternal age effects on offspring lifespan and reproduction vary within a species.Ecology and evolution · 2024Article
- A genome-wide screening of the 70 kDa heat shock protein (HSP70) genes in the rotifer Brachionus plicatilis sensu stricto with a characterization of two heat-inducible HSP70 genes.Cell stress & chaperones · 2023Article
- Highly efficient CRISPR-mediated gene editing in a rotifer.PLoS biology · 2023Article
- A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds.Biogerontology · 2021Article
- Brachionus rotifers as a model for investigating dietary and metabolic regulators of aging.Nutrition and healthy aging · 2021Review
- Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers.Molecules (Basel, Switzerland) · 2019Article
- The Natural History of Teneurins: A Billion Years of Evolution in Three Key Steps.Frontiers in neuroscience · 2019Article
- Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers.Biogerontology · 2018Article
- Genome-wide transcriptomics of aging in the rotifer Brachionus manjavacas, an emerging model system.BMC genomics · 2017Article
- Repurposing FDA-approved drugs for anti-aging therapies.Biogerontology · 2016Article
- Diapause and maintenance of facultative sexual reproductive strategies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions.Journal of visualized experiments : JoVE · 2016Article
- Moderately lower temperatures greatly extend the lifespan of Brachionus manjavacas (Rotifera): Thermodynamics or gene regulation?Experimental gerontology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Comparative biogerontology has much to contribute to the study of aging. A broad range of aging rates has evolved to meet environmental challenges, and understanding these adaptations can produce valuable insights into aging. The supra Phylum Lophotrochozoa is particularly understudied and has several groups that have intriguing patterns of aging. Members of the lophotrochozoan phylum Rotifera are particularly useful for aging studies because cohort life tables can be conducted with them easily, and biochemical and genomic tools are available for examining aging mechanisms. This paper reviews a variety of caloric restriction regimens, small molecule inhibitors, and dietary supplements that extend rotifer lifespan, as well as important interactions between caloric restriction and genotype, antioxidant supplements, and TOR and JNK pathways, and the use of RNAi to identify key genes involved in modulating the aging response. Examples of how rapamycin and JNK inhibitor exposure keeps mortality rates low during the reproductive phase of the life cycle are presented, and the ease of conducting life table experiments to screen natural products from red algae for life extending effects is illustrated. Finally, experimental evolution to produce longer-lived rotifer individuals is demonstrated, and future directions to determine the genetic basis of aging are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.