ArticleComments on modern chemistry. Part A, Comments on inorganic chemistry : a journal of critical discussion of the current literature2014
Targeted Chemotherapy with Metal Complexes.
Article in Comments on modern chemistry. Part A, Comments on inorganic chemistry : a journal of critical discussion of the current literature, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Metal-based triazoles as a medical marvel of the modern era: a comprehensive review.RSC advances · 2026Review
- Crystal Design, Antitumor Activity and Molecular Docking of Novel Palladium(II) and Gold(III) Complexes with a Thiosemicarbazone Ligand.International journal of molecular sciences · 2023Article
- Highlights of New Strategies to Increase the Efficacy of Transition Metal Complexes for Cancer Treatments.Molecules (Basel, Switzerland) · 2022Review
- Systemic Anticancer Therapy Details and Dental Adverse Effects in Children.International journal of environmental research and public health · 2022Article
- In vivo anticancer activity of a rhodium metalloinsertor in the HCT116 xenograft tumor model.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes.Molecules (Basel, Switzerland) · 2020Article
- Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies.Frontiers in chemistry · 2020Review
- Discovery of a Ruthenium Complex for the Theranosis of Glioma through Targeting the Mitochondrial DNA with Bioinformatic Methods.International journal of molecular sciences · 2019Article
- Clinical Risk Factors Influencing Dental Developmental Disturbances in Childhood Cancer Survivors.Cancer research and treatment · 2018Article
- Unusual Role of Excited State Mixing in the Enhancement of Photoinduced Ligand Exchange in Ru(II) Complexes.Journal of the American Chemical Society · 2017Article
- Rhodium metalloinsertor binding generates a lesion with selective cytotoxicity for mismatch repair-deficient cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Targeting DNA Mismatches with Rhodium Metalloinsertors.Inorganica chimica acta · 2016Article
- New Ru(II) Complex for Dual Activity: Photoinduced Ligand Release and (1)O2 Production.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- New Ru(II) complexes for dual photoreactivity: ligand exchange and (1)O2 generation.Accounts of chemical research · 2015Article
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3 authors.
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Abstract
Classical chemotherapeutics, such as cisplatin and its analogues, have been highly successful in the clinic, yet improvements can certainly be made, given the significant side effects associated with the killing of healthy cells. Recent advances in the field of chemotherapy include the development of targeted anticancer agents, compounds that are directed towards a specific biomarker of cancer, with the hopes that such targeted therapies might have reduced side effects given their greater selectivity. Here we discuss several transition metal complexes that are tailored towards various biomolecules associated with cancer. Most notably, the success of rhodium metalloinsertors, which specifically bind to nucleic acid base mismatches in DNA, highlight the enormous potential of this exciting new strategy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.