Evidence map›Paper›PMID 25641887›Full record

ArticleThe Journal of rheumatology2015

Urinary albumin excretion is increased in patients with rheumatoid arthritis and associated with arterial stiffness.

Karima Becetti, Annette Oeser, Michelle J Ormseth, Joseph F Solus, Paolo Raggi, C Michael Stein, Cecilia P Chung

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Efficacy and Safety of 22-Oxa-Calcitriol in Patients with Rheumatoid Arthritis: A Phase II Trial.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Karima BecettiFrom the Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA; the Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.K. Becetti, MD; A. Oeser, BS; M.J. Ormseth, MD, MSci; J.F. Solus, PhD, Department of Medicine, Vanderbilt University; P. Raggi, MD, Department of Medicine, University of Alberta; C.M. Stein, MD; C.P. Chung, MD, MPH, Department of Medicine, Vanderbilt University.
Annette OeserFrom the Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA; the Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.K. Becetti, MD; A. Oeser, BS; M.J. Ormseth, MD, MSci; J.F. Solus, PhD, Department of Medicine, Vanderbilt University; P. Raggi, MD, Department of Medicine, University of Alberta; C.M. Stein, MD; C.P. Chung, MD, MPH, Department of Medicine, Vanderbilt University.
Michelle J OrmsethFrom the Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA; the Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.K. Becetti, MD; A. Oeser, BS; M.J. Ormseth, MD, MSci; J.F. Solus, PhD, Department of Medicine, Vanderbilt University; P. Raggi, MD, Department of Medicine, University of Alberta; C.M. Stein, MD; C.P. Chung, MD, MPH, Department of Medicine, Vanderbilt University.
Joseph F SolusFrom the Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA; the Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.K. Becetti, MD; A. Oeser, BS; M.J. Ormseth, MD, MSci; J.F. Solus, PhD, Department of Medicine, Vanderbilt University; P. Raggi, MD, Department of Medicine, University of Alberta; C.M. Stein, MD; C.P. Chung, MD, MPH, Department of Medicine, Vanderbilt University.
Paolo RaggiFrom the Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA; the Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.K. Becetti, MD; A. Oeser, BS; M.J. Ormseth, MD, MSci; J.F. Solus, PhD, Department of Medicine, Vanderbilt University; P. Raggi, MD, Department of Medicine, University of Alberta; C.M. Stein, MD; C.P. Chung, MD, MPH, Department of Medicine, Vanderbilt University.
C Michael SteinFrom the Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA; the Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.K. Becetti, MD; A. Oeser, BS; M.J. Ormseth, MD, MSci; J.F. Solus, PhD, Department of Medicine, Vanderbilt University; P. Raggi, MD, Department of Medicine, University of Alberta; C.M. Stein, MD; C.P. Chung, MD, MPH, Department of Medicine, Vanderbilt University.
Cecilia P ChungFrom the Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA; the Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.K. Becetti, MD; A. Oeser, BS; M.J. Ormseth, MD, MSci; J.F. Solus, PhD, Department of Medicine, Vanderbilt University; P. Raggi, MD, Department of Medicine, University of Alberta; C.M. Stein, MD; C.P. Chung, MD, MPH, Department of Medicine, Vanderbilt University. c.chung@vanderbilt.edu.
Vanderbilt University · USGoethe Institute · GBSteinhauser (Czechia) · CZSUNY Geneseo · USUniversity of Alberta · CA

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
YOHIMBINE AS A MODEL OF ORTHOSTATIC INTOLERANCEM01RR000095 · NCRR · VANDERBILT UNIVERSITY · PI DRAKE, WONDER P. · 1985 to 2008
$38.3M
Vanderbilt Multidisciplinary Clinical Research CenterP60AR056116 · NIAMS · VANDERBILT UNIVERSITY · PI GRIFFIN, MARIE R. · 2008 to 2012
$6.2M
Drug-Drug Interactions and Preventable Adverse Events in RheumatologyK23AR064768 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHUNG, CECILIA PILAR · 2013 to 2016
$531k
NCATS NIH HHS 2 UL1 TR000445-06NCATS NIH HHS UL1 TR000445NCRR NIH HHS M01 RR000095NCRR NIH HHS UL1 RR024975NCRR NIH HHS UL1 RR024975-01NIAMS NIH HHS K23 AR064768NIAMS NIH HHS K23AR064768NIAMS NIH HHS P60 AR056116NIAMS NIH HHS P60AR056116NIGMS NIH HHS GM5M01-RR00095
6 · The paper itself

Abstract

objectiveRheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease (CVD). High urinary albumin excretion is a risk factor for CVD in the general population, but its role in atherosclerosis in patients with RA is not well defined.

methodsWe determined the urine albumin to creatinine ratio (UACR) in 136 patients with RA and 79 controls. Individuals with diabetes or a clinical history of CVD were excluded. We measured coronary artery calcium (CAC) with electron beam computer tomography and augmentation index (AIx) using pulse wave analysis. In patients with RA, erythrocyte sedimentation rate and concentrations of vascular cell adhesion protein-1 (VCAM-1), interleukin 10 (IL-10), C-reactive protein, IL-6, tumor necrosis factor-α, and cystatin-C were measured and results correlated with UACR.

resultsPatients with RA had higher UACR [median (interquartile range): 7.6 (4.0-15.5) mg/g] than control subjects: 5.6 (3.3-9.0) mg/g; p = 0.02. The presence of CAC was not associated with UACR in RA or control subjects. In patients with RA, UACR was significantly correlated with AIx (rho = 0.24, p = 0.01), higher levels of VCAM-1 (rho = 0.2, p = 0.01), and lower levels of IL-10 (rho = -0.2, p = 0.02). The association between AIx and higher UACR remained significant in multivariate analysis [β coefficient of 1.5 (95% CI 0.1-2.8), p = 0.03 that adjusted for age, sex, and race].

conclusionUrinary albumin excretion was higher in patients with RA than controls and correlated with increased arterial stiffness, higher VCAM-1, and lower IL-10 concentrations.

Indexed as

AdultAgedAlbuminuriaArthritis, RheumatoidC-Reactive ProteinCreatinineFemaleHumansInterleukin-10MaleMiddle AgedTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1Vascular StiffnessC-Reactive ProteinCreatinineInterleukin-10Tumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1ARTERIAL STIFFNESSATHEROSCLEROSISMICROALBUMINURIARHEUMATOID ARTHRITIS

Identifiers

PMID25641887
PMCPMC4383663
OpenAlexW2326136047

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.