ArticleJournal of biomedical materials research. Part A2015
An automated multidimensional thin film stretching device for the generation of anisotropic polymeric micro- and nanoparticles.
Article in Journal of biomedical materials research. Part A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Shape matters: Biodegradable anisotropic nanoparticle artificial antigen presenting cells for cancer immunotherapy.Acta biomaterialia · 2023Article
- Effects of Particle Geometry for PLGA-Based Nanoparticles: Preparation and In Vitro/In Vivo Evaluation.Pharmaceutics · 2023Article
- Preparation of Surface-Supported Polylactide Spherical-Cap Particles.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Anisotropic microparticles for differential drug release in nerve block anesthesia.RSC advances · 2021Article
- Biomimetic anisotropic polymeric nanoparticles coated with red blood cell membranes for enhanced circulation and toxin removal.Science advances · 2020Article
- Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization.Acta biomaterialia · 2019Article
- Polymeric Nanoparticles in Gene Therapy: New Avenues of Design and Optimization for Delivery Applications.Polymers · 2019Review
- Development of PLGA micro- and nanorods with high capacity of surface ligand conjugation for enhanced targeted delivery.Asian journal of pharmaceutical sciences · 2019Article
- Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation.Journal of visualized experiments : JoVE · 2018Article
- Anisotropic biodegradable lipid coated particles for spatially dynamic protein presentation.Acta biomaterialia · 2018Article
- Entanglement-Based Thermoplastic Shape Memory Polymeric Particles with Photothermal Actuation for Biomedical Applications.ACS applied materials & interfaces · 2018Article
- Surface engineering for lymphocyte programming.Advanced drug delivery reviews · 2017Review
- Effects of the Microparticle Shape on Cellular Uptake.Molecular pharmaceutics · 2016Article
- Biomimetic particles as therapeutics.Trends in biotechnology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Anisotropic polymeric particles are of growing interest for biomaterials applications due to their unique properties. These include the ability for these particles to evade nonspecific cellular uptake and to have enhanced targeted cellular uptake and interaction. One of the most widely used methods for generating anisotropic polymeric particles is the thin film stretching procedure. Despite its theoretical simplicity, this procedure, as it has been implemented to date, can be difficult due to the inconsistent nature of the manual operation of machinery used to stretch the film. We have constructed an automated thin film stretcher for control over biomaterials via thin film stretching in 1D and 2D and as a result, have enabled precise generation of anisotropic polymeric particles. We demonstrate that this device can be utilized to produce anisotropic biodegradable particles of different size, shape, and material consistency. Furthermore, we show that this machine has enabled the scaled up and rapid production of anisotropic polymeric particles, including polymeric microparticles that mimic the shape of red blood cells. Further application of this automated thin film stretching device could allow for significant impact to diverse biomaterial and biomedical applications such as biomimetic particles for immunoengineering and long-circulating particles for controlled release of drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.