Trial reportClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2015
Tremor in Charcot-Marie-Tooth disease: No evidence of cerebellar dysfunction.
Trial report in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The use of digital outcome measures in clinical trials in rare neurological diseases: a systematic literature review.Orphanet journal of rare diseases · 2023Pooled it
- EEG Microstate Alterations in Eyes-Open and Eyes-Closed Resting States Across the Alzheimer's Disease Continuum.Journal of clinical medicine · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Upper and lower limb tremor in Charcot-Marie-Tooth neuropathy type 1A and the implications for standing balance.Journal of neurology · 2024Article
- Tremor Following Guillain Barré Syndrome.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Roussy-Lévy Syndrome: Pes Cavus, Tendon Areflexia, Amyotrophy, Gait Ataxia, and Upper Limb Tremor in a Patient with CMT Neuropathy.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- A Critical Investigation of Cerebellar Associative Learning in Isolated Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021Review
- Charcot-Marie-Tooth: From Molecules to Therapy.International journal of molecular sciences · 2019Review
- Novel mutations in MYBPC1 are associated with myogenic tremor and mild myopathy.Annals of neurology · 2019Article
- [Genetics of tremor].Der Nervenarzt · 2018Review
- Studying cerebellar dysfunction in neuropathy-related tremor.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2015Article
- Highlighting the value of polymyography in childhood onset movement disorders.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTremor in Charcot-Marie-Tooth disease (CMT) can be disabling. Cerebellar abnormalities are thought to underpin neuropathic tremor. Here, we aim to clarify the potential role of the cerebellum in CMT tremor.
methodsWe assessed prevalence of tremor by questionnaire in 84 patients with CMT. Of those, 23 patients with CMT with and without arm tremor and healthy controls underwent a clinical assessment, classical eyeblink conditioning, electro-oculography, visuomotor adaptation test, tremor recording with surface EMG and accelerometry, and retrospective correlation with nerve conduction studies to investigate the possible mechanisms of tremor generation.
resultsThe prevalence study revealed tremor in 21% of patients and in 42% of those it caused impairment of function. Tremor recordings revealed a mild-to-moderate amplitude tremor with a weight load-invariant 7.7 Hz frequency component. Performance on classical eyeblink conditioning, visuomotor adaptation and electro-oculography were no different between tremulous and non-tremulous patients and healthy controls.
conclusionsThese results argue against a prominent role for an abnormal cerebellum in tremor generation in the patients studied with CMT. Rather, our results suggest an enhancement of the central neurogenic component of physiological tremor as a possible mechanism for tremor in the patients studied. SIGNIFICANCE: This study is the first to propose differing pathogenic mechanisms for subtypes of neuropathic tremor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.