ArticleRespiratory physiology & neurobiology2015
Impact of unilateral denervation on transdiaphragmatic pressure.
Article in Respiratory physiology & neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 33 citations in OpenAlex.
- Impact of upper cervical spinal cord hemisection on diaphragm neuromotor control.Journal of neurophysiology · 2025Article
- A Simple, Low-Cost Implant for Reliable Diaphragm EMG Recordings in Awake, Behaving Rats.eNeuro · 2025Article
- Hypercapnia impacts neural drive and timing of diaphragm neuromotor control.Journal of neurophysiology · 2024Article
- Cervical spinal cord hemisection impacts sigh and the respiratory reset in male rats.Physiological reports · 2024Article
- Neuromotor control of spontaneous quiet breathing in awake rats evaluated by assessments of diaphragm EMG stationarity.Journal of neurophysiology · 2023Article
- Chloroquine impairs maximal transdiaphragmatic pressure generation in old mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Novel regenerative drug, SPG302 promotes functional recovery of diaphragm muscle activity after cervical spinal cord injury.The Journal of physiology · 2023Article
- Automated evaluation of respiratory signals to provide insight into respiratory drive.Respiratory physiology & neurobiology · 2022Article
- Acute intrathecal BDNF enhances functional recovery after cervical spinal cord injury in rats.Journal of neurophysiology · 2021Article
- TrkB signaling contributes to transdiaphragmatic pressure generation in aged mice.Journal of neurophysiology · 2021Article
- Inhibition of TrkB kinase activity impairs transdiaphragmatic pressure generation.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Diaphragm muscle sarcopenia into very old age in mice.Physiological reports · 2020Article
- Diaphragm Muscle Adaptations in Health and Disease.Drug discovery today. Disease models · 2019Article
- Diaphragm muscle function following midcervical contusion injury in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Phrenic motoneuron structural plasticity across models of diaphragm muscle paralysis.The Journal of comparative neurology · 2018Article
- Impact of aging on diaphragm muscle function in male and female Fischer 344 rats.Physiological reports · 2018Article
- Phrenic motor neuron loss in aged rats.Journal of neurophysiology · 2018Article
- Diaphragm muscle activity across respiratory motor behaviors in awake and lightly anesthetized rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Breathing: Motor Control of Diaphragm Muscle.Physiology (Bethesda, Md.) · 2018Review
- Compensatory effects following unilateral diaphragm paralysis.Respiratory physiology & neurobiology · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The diaphragm muscle (DIAm) has a large reserve capacity for force generation such that in rats, the transdiaphragmatic pressure (Pdi) generated during ventilatory behaviors is less than 50% of maximal Pdi (Pd(imax)) elicited by bilateral phrenic nerve stimulation. Accordingly, we hypothesized that following unilateral denervation (DNV), the ability of the contralateral DIAm to generate sufficient Pdi to accomplish ventilatory behaviors will not be compromised and normal ventilation (as determined by arterial blood gas measurements) will not be impacted, although neural drive to the DIAm increases. In contrast, we hypothesized that higher force, non-ventilatory behaviors requiring Pdi generation greater than 50% of Pd(imax) will be compromised following DIAm hemiparalysis, i.e., increased neural drive cannot fully compensate for lack of force generating capacity. Pdi generated during ventilatory behaviors (eupnea and hypoxia (10% O2)-hypercapnia (5% CO2)) did not change after DNV and arterial blood gases were unaffected by DNV. However, neural drive to the contralateral DIAm, assessed by the rate of rise of root mean squared (RMS) EMG at 75 ms after onset of inspiratory activity (RMS75), increased after DNV (p<0.05). In contrast, Pdi generated during higher force, non-ventilatory behaviors was significantly reduced after DNV (p < 0.01), while RMS75 was unchanged. These findings support our hypothesis that only non-ventilatory behaviors requiring Pdi generation greater than 50% of Pd(imax) are impacted after DNV. Clinically, these results indicate that an evaluation of DIAm weakness requires examination of Pdi across multiple motor behaviors, not just ventilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.