Evidence map›Paper›PMID 25641235›Full record

ArticleScientific reports2015

Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure.

Corinna Glasner, Mirjan M van Timmeren, Tim Stobernack, Till F Omansen, Erwin C Raangs, John W Rossen, Marcus C de Goffau, Jan P Arends, Greetje A Kampinga, Denny G A M Koedijk and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  3. Upper Respiratory Microbiome in Vasculitis.Rheumatic diseases clinics of North America · 2025
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  5. Impact ofMicroorganisms · 2022
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  6. Review
  7. Granulomatous Inflammation in ANCA-Associated Vasculitis.International journal of molecular sciences · 2021
    Review
  8. Review
  9. The microbiome in autoimmune rheumatic disease.Best practice & research. Clinical rheumatology · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Corinna GlasnerDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Mirjan M van TimmerenDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Tim StobernackDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Till F OmansenDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Erwin C RaangsDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
John W RossenDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Marcus C de GoffauDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Jan P ArendsDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Greetje A KampingaDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Denny G A M KoedijkDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Jolanda NeefDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Girbe BuistDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Mehri TavakolDepartment of Medical Microbiology and Infectious Diseases, Erasmus MC, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
Willem J B van WamelDepartment of Medical Microbiology and Infectious Diseases, Erasmus MC, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
Abraham RutgersDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Coen A StegemanDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Cees G M KallenbergDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Peter HeeringaDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Jan Maarten van DijlDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1P.O. Box 30001, 9700 RB Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NLErasmus MC · NLErasmus University Rotterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy carriers, nor whether specific S. aureus types are associated with GPA. Therefore, this study was aimed at assessing humoral immune responses of GPA patients against S. aureus antigens in relation to the genetic diversity of their nasal S. aureus isolates. A retrospective cohort study was conducted, including 85 GPA patients and 18 healthy controls (HC). Humoral immune responses against S. aureus were investigated by determining serum IgG levels against 59 S. aureus antigens. Unexpectedly, patient sera contained lower anti-staphylococcal IgG levels than sera from HC, regardless of the patients' treatment, while total IgG levels were similar or higher. Furthermore, 210 S. aureus isolates obtained from GPA patients were characterized by different typing approaches. This showed that the S. aureus population of GPA patients is highly diverse and mirrors the general S. aureus population. Our combined findings imply that GPA patients are less capable of mounting a potentially protective antibody response to S. aureus than healthy individuals.

Indexed as

AdultAgedAnti-Bacterial AgentsAntibodies, BacterialCohort StudiesDrug Resistance, BacterialFemaleGranulomatosis with PolyangiitisHumansImmunoglobulin GMaleMicrobial Sensitivity TestsMiddle AgedRetrospective StudiesStaphylococcus aureusAnti-Bacterial AgentsAntibodies, BacterialImmunoglobulin G

Identifiers

PMID25641235
PMCPMC5389034
OpenAlexW1991220569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.