Evidence map›Paper›PMID 25641213›Full record

ArticleScientific reports2015

Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease.

Peng Chen, Hai Yan, Yaping Tian, Yiping Xun, Lili Shi, Ran Bao, Huai Zhang, Guangyu Chen, Chunhe Yang, Shutao Sun and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Annexin A2: A Double-Edged Sword in Pathogen Infection.Pathogens (Basel, Switzerland) · 2024
    Review
  2. Review
  3. Review
  4. The important roles and molecular mechanisms of annexin AAnnals of translational medicine · 2021
    Article
  5. Review
  6. Article
  7. Article
  8. PGK1 as an immune target in Kawasaki disease.Clinical and experimental immunology · 2018
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Peng ChenSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Hai YanSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Yaping TianDepartment of Clinical Biochemistry, Chinese PLA General Hospital, Beijing 100853, China.
Yiping XunSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Lili ShiSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Ran BaoSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Huai ZhangSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Guangyu ChenImmunoHunt Corporation, 139 Fengtai Rd, Beijing 100071, China.
Chunhe YangSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Shutao SunCore Facility, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Yajie Wang1] Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China [2] Department of Clinical Laboratory Diagnosis, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
Li LiuCore Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
Yabin ZhouSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Chunyan ZhangDepartment of Clinical Biochemistry, Chinese PLA General Hospital, Beijing 100853, China.
Xiaoxu WangSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Yongqiang WenSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Yongzhong BianSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Hongwu DuSchool of Chemistry and Biotechnology Engineering, University of Science and Technology Beijing, Beijing 100083, China.
University of Science and Technology Beijing · CNCapital Medical University · CNChinese PLA General Hospital · CNInstitute of Microbiology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell membrane proteins are believed to play a critical role in the pathogenesis of autoimmune diseases. However, few membrane autoantigens have been linked with Behçet's disease. Here, a cell-chip was performed to identify autoantibody target cells, and the suspected autoantigens were detected using immunoblotting. The amino acid sequences of the detected proteins were determined using LC-MALDI-TOF/TOF. Putative proteins were recombinantly expressed and purified, and a corresponding ELISA was developed and clinically validated using real clinical samples. It was found that a 36-kDa membrane protein--annexin A2--was detected in approximately one-third of the patients' blood circulation. The immunohistochemistry results showed that annexin A2 was highly expressed in vascular endothelial cells. Moreover, vascular involvement was significantly higher in the anti-annexin A2 antibody-positive group versus the anti-annexin A2 antibody-negative group among all the clinical samples analyzed, indicating that annexin A2 is a novel endothelial cell membrane antigen involved in Behçet's disease.

Indexed as

AdolescentAdultAgedAnnexin A2AutoantibodiesAutoantigensBehcet SyndromeCell LineCell MembraneChaperonin 60Endothelium, VascularFemaleHumansMaleMiddle AgedMitochondrial ProteinsAnnexin A2AutoantibodiesAutoantigensChaperonin 60HSPD1 protein, humanMitochondrial ProteinsRecombinant Proteins

Identifiers

PMID25641213
PMCPMC4313095
OpenAlexW2033806042

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.