Evidence map›Paper›PMID 25640961›Full record

ArticleStatistics in medicine2015

Using distance covariance for improved variable selection with application to learning genetic risk models.

Jing Kong, Sijian Wang, Grace Wahba

Abstract read
In one paragraph

Article in Statistics in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jing KongDepartment of Statistics, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI, 53706, U.S.A.
Sijian Wang
Grace Wahba

Funding

NEW STATISTICAL METHODS FOR DEMOGRAPHIC DATA ANALYSISR01EY009946 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI WAHBA, GRACE · 1993 to 2012
$2.9M
Heterogenous and Robust Survival Analysis in Genomic StudiesR01HG007377 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, SIJIAN · 2014 to 2017
$1.0M
NEI NIH HHS EY009946NEI NIH HHS R01 EY009946NHGRI NIH HHS 5R01 HG007377-02NHGRI NIH HHS R01 HG007377
6 · The paper itself

Abstract

Variable selection is of increasing importance to address the difficulties of high dimensionality in many scientific areas. In this paper, we demonstrate a property for distance covariance, which is incorporated in a novel feature screening procedure together with the use of distance correlation. The approach makes no distributional assumptions for the variables and does not require the specification of a regression model and hence is especially attractive in variable selection given an enormous number of candidate attributes without much information about the true model with the response. The method is applied to two genetic risk problems, where issues including uncertainty of variable selection via cross validation, subgroup of hard-to-classify cases, and the application of a reject option are discussed.

Indexed as

Genetic Predisposition to DiseaseModels, GeneticAnalysis of VarianceAntineoplastic AgentsBinomial DistributionDiagnosis, DifferentialFemaleGenes, NeoplasmGenetic TestingHumansOvarian NeoplasmsPharmacogeneticsRisk AssessmentAntineoplastic Agentsdistance correlationpenalized Bernoulli likelihoodSVM with reject optionTCGA ovarian cancer datavariable selection

Identifiers

PMID25640961
PMCPMC4441212

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.