Evidence map›Paper›PMID 25640903›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015

The effect of tendon excursion velocity on longitudinal median nerve displacement: differences between carpal tunnel syndrome patients and controls.

Anika Filius, Andrew R Thoreson, Yuexiang Wang, Sandra M Passe, Chunfeng Zhao, Kai-Nan An, Peter C Amadio

Open access · greenAbstract readControlled Clinical Trial
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Grip Force Modulation on Median Nerve Morphology Changes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Carpal Tunnel Syndrome Treatment and the Subsequent Alterations in Median Nerve Transverse Mobility.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Anika FiliusBiomechanics Laboratory and the Tendon & Soft Tissue Biology Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, Minnesota; Department of Plastic, Reconstructive and Hand Surgery, and the Department of Rehabilitation Medicine and Physical Therapy, Erasmus Medical Center, Rotterdam, The Netherlands.
Andrew R Thoreson
Yuexiang Wang
Sandra M Passe
Chunfeng Zhao
Kai-Nan An
Peter C Amadio
Mayo Clinic · USErasmus MC · NL

Funding

Dynamic Ultrasound to Enhance Understanding of Carpal Tunnel SyndromeR01AR062613 · NIAMS · MAYO CLINIC ROCHESTER · PI AMADIO, PETER C. · 2014 to 2018
$1.7M
NIAMS NIH HHS R01 AR062613
6 · The paper itself

Abstract

The subsynovial connective tissue (SSCT) is a viscoelastic structure connecting the median nerve (MN) and the flexor tendons in the carpal tunnel. Increased strain rates increases stiffness in viscoelastic tissues, and thereby its capacity to transfer shear load. Therefore, tendon excursion velocity may impact the MN displacement. In carpal tunnel syndrome (CTS) the SSCT is fibrotic and may be ruptured, and this may affect MN motion. In this study, ultrasonography was performed on 14 wrists of healthy controls and 25 wrists of CTS patients during controlled finger motions performed at three different velocities. Longitudinal MN and tendon excursion were assessed using a custom speckle tracking algorithm and compared across the three different velocities. CTS patients exhibited significantly less MN motion than controls (p ≤ 0.002). While in general, MN displacement increased with increasing tendon excursion velocity (p ≤ 0.031). These findings are consistent with current knowledge of SSCT mechanics in CTS, in which in some patients the fibrotic SSCT appears to have ruptured from the tendon surface.

Indexed as

AdultBiomechanical PhenomenaCarpal Tunnel SyndromeFemaleFingersHumansMaleMedian NerveMiddle AgedMovementTendonsUltrasonographycarpal tunnelflexor tendonsmedian nerveultrasoundvelocity

Identifiers

PMID25640903
PMCPMC5168720
OpenAlexW2109646858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.