Trial reportDevelopment and psychopathology2015
The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants.
Trial report in Development and psychopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of gene-by-intervention studies of alcohol and other substance use.Development and psychopathology · 2021Pooled it
- Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse.Prevention science : the official journal of the Society for Prevention Research · 2018Trial
- Early musical training benefits to non-musical cognitive ability associated with the Gestalt principles.Frontiers in psychology · 2023Article
- A review of psychosocial factors linked to adolescent substance use.Pharmacology, biochemistry, and behavior · 2020Review
- Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention.Development and psychopathology · 2018Article
- Transactions Between Substance Use Intervention, the Oxytocin Receptor (OXTR) Gene, and Peer Substance Use Predicting Youth Alcohol Use.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Extending Previous cG×I Findings on 5-HTTLPR's Moderation of Intervention Effects on Adolescent Substance Misuse Initiation.Child development · 2017Article
- Neuroplasticity of selective attention: Research foundations and preliminary evidence for a gene by intervention interaction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene-environment interaction in a 30-day ecological momentary assessment study.Development and psychopathology · 2016Article
- An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Differential Susceptibility: The Genetic Moderation of Peer Pressure on Alcohol Use.Journal of youth and adolescence · 2015Article
- Looking Forward in Candidate Gene Research: Concerns and Suggestions.Journal of marriage and the family · 2015Article
- Developmental differences in early adolescent aggression: a gene × environment × intervention analysis.Journal of youth and adolescence · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Data drawn from the in-home subsample of the PROSPER intervention dissemination trial were used to investigate the moderation of intervention effects on underage alcohol use by maternal involvement and candidate genes. The primary gene examined was dopamine receptor D4 (DRD4). Variation in this gene and maternal involvement were hypothesized to moderate the influence of intervention status on alcohol use. The PROSPER data used were drawn from 28 communities randomly assigned to intervention or comparison conditions. Participating youth were assessed in five in-home interviews from sixth to ninth grades. A main effect of sixth-grade pretest maternal involvement on ninth-grade alcohol use was found. Neither intervention status nor DRD4 variation was unconditionally linked to ninth-grade drinking. However, moderation analyses revealed a significant three-way interaction among DRD4 status, maternal involvement, and intervention condition. Follow-up analyses revealed that prevention reduced drinking risk, but only for youth with at least one DRD4 seven-repeat allele who reported average or greater pretest levels of maternal involvement. To determine if this conditional pattern was limited to the DRD4 gene, we repeated analyses using the serotonin transporter linked polymorphic region site near the serotonin transporter gene. The results for this supplemental analysis revealed a significant three-way interaction similar but not identical to that found for DRD4.
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