ArticleStem cell reports2015
Stable X chromosome reactivation in female human induced pluripotent stem cells.
Article in Stem cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes.Genome biology · 2024Article
- LRP10 and α-synuclein transmission in Lewy body diseases.Cellular and molecular life sciences : CMLS · 2024Article
- Preventing erosion of X-chromosome inactivation in human embryonic stem cells.Nature communications · 2022Article
- Generation of Induced Pluripotent Stem Cells from a Female Patient with a Xq27.3-q28 Deletion to Establish Disease Models and Identify Therapies.Cellular reprogramming · 2020Article
- Review
- Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases.Acta neuropathologica · 2020Article
- Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency.Genomics, proteomics & bioinformatics · 2020Review
- Association of Human iPSC Gene Signatures and X Chromosome Dosage with Two Distinct Cardiac Differentiation Trajectories.Stem cell reports · 2019Article
- Induced pluripotent stem cells, a giant leap for mankind therapeutic applications.World journal of stem cells · 2019Review
- Generation of Isogenic Controls for In Vitro Disease Modelling of X-Chromosomal Disorders.Stem cell reviews and reports · 2019Article
- Electrophysiological abnormalities in induced pluripotent stem cell-derived cardiomyocytes generated from Duchenne muscular dystrophy patients.Journal of cellular and molecular medicine · 2019Article
- Recent Advances in Understanding the Reversal of Gene Silencing During X Chromosome Reactivation.Frontiers in cell and developmental biology · 2019Review
- Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells.Cell stem cell · 2018Article
- Involvement of X-chromosome Reactivation in Augmenting Cancer Testis Antigens Expression: A Hypothesis.Current medical science · 2018Article
- Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI.Genome research · 2018Article
- Regulation of X-chromosome dosage compensation in human: mechanisms and model systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Reprogramming human cells to naïve pluripotency: how close are we?Current opinion in genetics & development · 2017Review
- Allele-specific analysis of cell fusion-mediated pluripotent reprograming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation.Genome biology · 2017Article
- Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation.Cell reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In placental mammals, balanced expression of X-linked genes is accomplished by X chromosome inactivation (XCI) in female cells. In humans, random XCI is initiated early during embryonic development. To investigate whether reprogramming of female human fibroblasts into induced pluripotent stem cells (iPSCs) leads to reactivation of the inactive X chromosome (Xi), we have generated iPSC lines from fibroblasts heterozygous for large X-chromosomal deletions. These fibroblasts show completely skewed XCI of the mutated X chromosome, enabling monitoring of X chromosome reactivation (XCR) and XCI using allele-specific single-cell expression analysis. This approach revealed that XCR is robust under standard culture conditions, but does not prevent reinitiation of XCI, resulting in a mixed population of cells with either two active X chromosomes (Xas) or one Xa and one Xi. This mixed population of XaXa and XaXi cells is stabilized in naive human stem cell medium, allowing expansion of clones with two Xas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.