Evidence map›Paper›PMID 25640636›Full record

ArticleHeart rhythm2015

Remodeling of stellate ganglion neurons after spatially targeted myocardial infarction: Neuropeptide and morphologic changes.

Olujimi A Ajijola, Daigo Yagishita, Naveen K Reddy, Kentaro Yamakawa, Marmar Vaseghi, Anthony M Downs, Donald B Hoover, Jeffrey L Ardell, Kalyanam Shivkumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.

  1. The relevance of the superior cervical ganglion for cardiac autonomic innervation in health and disease: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Pooled it
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  11. Hypertension-induced heart failure disrupts cardiac sympathetic innervation.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  12. Non-invasive Neuromodulation of Arrhythmias.Cardiac electrophysiology clinics · 2024
    Review
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Olujimi A AjijolaUCLA Cardiac Arrhythmia Center, University of California-Los Angeles, Los Angeles, California; Neurocardiology Research Center of Excellence, University of California-Los Angeles, Los Angeles, California.
Daigo YagishitaUCLA Cardiac Arrhythmia Center, University of California-Los Angeles, Los Angeles, California.
Naveen K ReddyUCLA Cardiac Arrhythmia Center, University of California-Los Angeles, Los Angeles, California.
Kentaro YamakawaDepartment of Cardiac Anesthesia, University of California-Los Angeles, Los Angeles, California.
Marmar VaseghiUCLA Cardiac Arrhythmia Center, University of California-Los Angeles, Los Angeles, California; Neurocardiology Research Center of Excellence, University of California-Los Angeles, Los Angeles, California.
Anthony M DownsDepartment of Biomedical Sciences, Center for Inflammation, Infectious Disease, and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Donald B HooverDepartment of Biomedical Sciences, Center for Inflammation, Infectious Disease, and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Jeffrey L ArdellUCLA Cardiac Arrhythmia Center, University of California-Los Angeles, Los Angeles, California; Neurocardiology Research Center of Excellence, University of California-Los Angeles, Los Angeles, California.
Kalyanam ShivkumarUCLA Cardiac Arrhythmia Center, University of California-Los Angeles, Los Angeles, California; Neurocardiology Research Center of Excellence, University of California-Los Angeles, Los Angeles, California. Electronic address: kshivkumar@mednet.ucla.edu.
University of California, Los Angeles · USEast Tennessee State University · US

Funding

ELECTROPHYSIOLOGICAL EFFECTS OF NEURAL REMODELING OF THE VENTRICLESR01HL084261 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM · 2006 to 2016
$3.4M
Antiarrhythmic Mechanisms of Bilateral Cardiac Sympathetic DecentralizationK08HL125730 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A · 2015 to 2019
$833k
Cholinergic anti-inflammatory mechanisms in sepsis and septic shockR15GM107949 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI HOOVER, DONALD B · 2014 to 2014
$337k
NHLBI NIH HHS K08 HL125730NHLBI NIH HHS R01 HL084261NHLBI NIH HHS R01HL084261NIGMS NIH HHS GM107949NIGMS NIH HHS R15 GM107949
6 · The paper itself

Abstract

backgroundMyocardial infarction (MI) induces remodeling in stellate ganglion neurons (SGNs).

objectiveWe investigated whether infarct site has any impact on the laterality of morphologic changes or neuropeptide expression in stellate ganglia.

methodsYorkshire pigs underwent left circumflex coronary artery (LCX; n = 6) or right coronary artery (RCA; n = 6) occlusion to create left- and right-sided MI, respectively (control: n = 10). At 5 ± 1 weeks after MI, left and right stellate ganglia (LSG and RSG, respectively) were collected to determine neuronal size, as well as tyrosine hydroxylase (TH) and neuropeptide Y immunoreactivity.

resultsCompared with control, LCX and RCA MIs increased mean neuronal size in the LSG (451 ± 25 vs 650 ± 34 vs 577 ± 55 μm(2), respectively; P = .0012) and RSG (433 ± 22 vs 646 ± 42 vs 530 ± 41 μm(2), respectively; P = .002). TH immunoreactivity was present in the majority of SGNs. Both LCX and RCA MIs were associated with significant decreases in the percentage of TH-negative SGNs, from 2.58% ± 0.2% in controls to 1.26% ± 0.3% and 0.7% ± 0.3% in animals with LCX and RCA MI, respectively, for LSG (P = .001) and from 3.02% ± 0.4% in controls to 1.36% ± 0.3% and 0.68% ± 0.2% in LCX and RCA MI, respectively, for RSG (P = .002). Both TH-negative and TH-positive neurons increased in size after LCX and RCA MI. Neuropeptide Y immunoreactivity was also increased significantly by LCX and RCA MI in both ganglia.

conclusionLeft- and right-sided MIs equally induced morphologic and neurochemical changes in LSG and RSG neurons, independent of infarct site. These data indicate that afferent signals transduced after MI result in bilateral changes and provide a rationale for bilateral interventions targeting the sympathetic chain for arrhythmia modulation.

Indexed as

Myocardial InfarctionNeuronal PlasticityStellate GanglionAnimalsCoronary VesselsDisease Models, AnimalElectrocardiographyNeuronsNeuropeptide YSpatial AnalysisSwineTyrosine 3-MonooxygenaseNeuropeptide YTyrosine 3-MonooxygenaseAutonomic nervous systemMyocardial infarctionNeuronal remodelingNeuropeptide remodelingSympathetic ganglia

Identifiers

PMID25640636
PMCPMC4411181
OpenAlexW2066637821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.