ArticleEpidemiology and infection2015
Clinical predictors of disease severity during the 2009-2010 A(HIN1) influenza virus pandemic in a paediatric population.
Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis.European journal of pediatrics · 2023Pooled it
- Predicting poor outcomes in children aged 1-12 with respiratory tract infections: A systematic review.PloS one · 2021Pooled it
- Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials.Expert review of anti-infective therapy · 2017Pooled it
- Trends and Non-Clinical Predictors of Respiratory Syncytial Virus (RSV) and Influenza Diagnosis in an Urban Pediatric Population.International journal of pediatric research · 2023Article
- Vaccination in preterm and low birth weight infants in India.Human vaccines & immunotherapeutics · 2022Review
- Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses.Viruses · 2022Article
- Sex differences in susceptibility to influenza A virus infection depend on host genotype.PloS one · 2022Article
- Children and Adolescents with Disabilities and Exposure to Disasters, Terrorism, and the COVID-19 Pandemic: a Scoping Review.Current psychiatry reports · 2021Article
- Retrospective study of the use of an influenza disease two-tiered classification system to characterize clinical severity in US children.Human vaccines & immunotherapeutics · 2020Article
- Mortality risk factors in children with severe influenza virus infection admitted to the pediatric intensive care unit.Medicine · 2019Article
- Is weight associated with severity of acute respiratory illness?International journal of obesity (2005) · 2018Article
- Impact of Asthma on the Association between Childhood Obesity and Influenza.JSM allergy and asthma · 2017Article
- Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination?Frontiers in microbiology · 2017Article
- Retrospective review of factors associated with severe hospitalised community-acquired influenza in a tertiary paediatric hospital in South Australia.Influenza and other respiratory viruses · 2016Article
- Impact of A/H1N1 influenza in children at a Brazilian University Hospital.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
- Insights in paediatric virology during the COVID-19 era (Review).Medicine internationalReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel influenza virus emerged in the United States in spring 2009, rapidly becoming a global pandemic. Children were disproportionally affected by the novel influenza A(H1N1) pandemic virus [A(H1N1)pdm]. This retrospective electronic medical record review study aimed to identify clinical predictors of disease severity of influenza A(HIN1)pdm infection in paediatric patients. Disease severity was defined on an increasing three-level scale from non-hospitalized, hospitalized, and admitted to the intensive care unit (ICU). From April 2009 to June 2010, 696 children presented to Texas Children's Hospital's emergency department, 38% were hospitalized, and 17% were admitted to the ICU. Presenting symptoms associated with severe influenza were dyspnoea [odds ratio (OR) 5·82], tachycardia (OR 2·61) and fatigue (OR 1·96). Pre-existing health conditions associated with disease severity included seizure disorder (OR 4·71), obesity (OR 3·28), lung disease (OR 2·84), premature birth (OR 2·53), haematological disease (OR 2·22), and developmental delay (OR 2·20). According to model fitness tests, presenting symptoms were more likely to predict severe influenza than underlying medical conditions. However, both are important risk factors. Recognition of clinical characteristics associated with severe disease can be used for triaging case management of children during future influenza outbreaks.
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