ArticleGenes, brain, and behavior2015
Aggression is associated with aerobic glycolysis in the honey bee brain(1).
Article in Genes, brain, and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 79 citations in OpenAlex.
- A bioenergetic understanding of "aerobic glycolysis".Communications biology · 2026Review
- Differential expression of neuronal function genes follows a tissue-specific temporal dynamic during Deformed Wing Virus infection in honeybees.Scientific reports · 2026Article
- Transcriptomic investigation of agonistic behaviors of boxer shrimps (Stenopus species): insights into the potential neural signaling roles of dopamine and acetylcholine.BMC genomics · 2026Article
- Dopamine enhances surface glial glycolysis via acetylcholine and insulin/insulin-like growth factor signaling in the honeybee.iScience · 2026Article
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- Substantial variation in larval honey bee nutrition within and among Apis mellifera colonies.PloS one · 2026Article
- Do honey phytochemicals modulate forager aggression and the gut microbiome in the honey bee (Apis mellifera L.)?Biology open · 2025Article
- Integrated Transcriptomic and Metabolomic Insights into "I See You" (ISY) Defensive Behavior inInsects · 2025Article
- Integrating Deep Learning and Transcriptomics to Assess Livestock Aggression: A Scoping Review.Biology · 2025Review
- Division of labour during honeybee colony defence: poetic and scientific views.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Remodeling of Cellular Respiration and Insulin Signaling Are Part of a Shared Stress Response in Divergent Bee Species.Insects · 2025Article
- The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host.BMC genomics · 2025Article
- Brain transcriptomics of a social challenge and maternal aggression in incubating female tree swallows.Hormones and behavior · 2025Article
- Metabolic pathway modulation by olanzapine: Multitarget approach for treating violent aggression in patients with schizophrenia.World journal of psychiatry · 2025Article
- Brain energy metabolism as an underlying basis of slow and fast cognitive phenotypes in honeybees.The Journal of experimental biology · 2024Article
- Methodology for Single Bee and Bee BrainMetabolites · 2021Article
- Article
- Dynamic neurogenomic responses to social interactions and dominance outcomes in female paper wasps.PLoS genetics · 2021Article
- Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Aerobic glycolysis involves increased glycolysis and decreased oxidative catabolism of glucose even in the presence of an ample oxygen supply. Aerobic glycolysis, a common metabolic pattern in cancer cells, was recently discovered in both the healthy and diseased human brain, but its functional significance is not understood. This metabolic pattern in the brain is surprising because it results in decreased efficiency of adenosine triphosphate (ATP) production in a tissue with high energetic demands. We report that highly aggressive honey bees (Apis mellifera) show a brain transcriptomic and metabolic state consistent with aerobic glycolysis, i.e. increased glycolysis in combination with decreased oxidative phosphorylation. Furthermore, exposure to alarm pheromone, which provokes aggression, causes a metabolic shift to aerobic glycolysis in the bee brain. We hypothesize that this metabolic state, which is associated with altered neurotransmitter levels, increased glycolytically derived ATP and a reduced cellular redox state, may lead to increased neuronal excitability and oxidative stress in the brain. Our analysis provides evidence for a robust, distinct and persistent brain metabolic response to aggression-inducing social cues. This finding for the first time associates aerobic glycolysis with naturally occurring behavioral plasticity, which has important implications for understanding both healthy and diseased brain function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.