ArticleThe journal of pain2015
Enhanced nonpeptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch.
Article in The journal of pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Acetone-Ether-Water Mouse Model of Persistent Itch Fully Resolves Without Latent Pruritic or Cross-Modality Priming.Dermatopathology (Basel, Switzerland) · 2025Article
- Article
- Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice.Neuroscience bulletin · 2022Article
- IL-33 signaling in sensory neurons promotes dry skin itch.The Journal of allergy and clinical immunology · 2022Article
- Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala.eLife · 2021Article
- Itch and Cough - Similar Role of Sensory Nerves in Their Pathogenesis.Physiological research · 2020Review
- Mechanisms and Management of Itch in Dry Skin.Acta dermato-venereologica · 2020Review
- Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray.Nature communications · 2019Article
- Altered expression of itch‑related mediators in the lower cervical spinal cord in mouse models of two types of chronic itch.International journal of molecular medicine · 2019Article
- Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development.Scientific reports · 2019Article
- Interactions of the immune and sensory nervous systems in atopy.The FEBS journal · 2018Review
- Peripheral and Central Mechanisms of Itch.Neuron · 2018Review
- Mrgprs activation is required for chronic itch conditions in mice.Itch (Philadelphia, Pa.) · 2017Article
- Article
- Altered expression of target genes of spinal cord in different itch models compared with capsaicin assessed by RT-qPCR validation.Oncotarget · 2017Article
- Article
- TFOS DEWS II pain and sensation report.The ocular surface · 2017Review
- Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.Nature protocols · 2016Article
- Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice.BioMed research international · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledChronic pruritic conditions are often associated with dry skin and loss of epidermal barrier integrity. In this study, repeated application of acetone and ether followed by water (AEW) to the cheek skin of mice produced persistent scratching behavior with no increase in pain-related forelimb wiping, indicating the generation of itch without pain. Cheek skin immunohistochemistry showed a 64.5% increase in total epidermal innervation in AEW-treated mice compared to water-treated controls. This increase was independent of scratching, because mice prevented from scratching by Elizabethan collars showed similar hyperinnervation. To determine the effects of dry skin treatment on specific subsets of peripheral fibers, we examined Ret-positive, calcitonin gene-related peptide (CGRP)-positive, and glial cell line-derived neurotrophic factor family receptor α3 (GFRα3)-positive intraepidermal fiber density. AEW treatment increased Ret-positive fibers but not CGRP-positive or GFRα3-positive fibers, suggesting that a specific subset of nonpeptidergic fibers could contribute to dry skin itch. To test whether trigeminal ganglion neurons innervating the cheek exhibited altered excitability after AEW treatment, primary cultures of retrogradely labeled neurons were examined using whole-cell patch clamp electrophysiology. AEW treatment produced no differences in measures of excitability compared to water-treated controls. In contrast, a significantly higher proportion of trigeminal ganglion neurons was responsive to the nonhistaminergic pruritogen chloroquine after AEW treatment. We conclude that nonpeptidergic, Ret-positive fibers and chloroquine-sensitive neurons may contribute to dry skin pruritus. PERSPECTIVE: This study examines the underlying neurobiological mechanisms of persistent dry skin itch. Our results indicate that nonpeptidergic epidermal hyperinnervation and nonhistaminergic pruritic receptors are potential targets for chronic pruritus.
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