Trial reportJournal of pain and symptom management2015
Feasibility of Conducting a Palliative Care Randomized Controlled Trial in Children With Advanced Cancer: Assessment of the PediQUEST Study.
Trial report in Journal of pain and symptom management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The PediQUEST Study: Evaluation of Pediatric Quality of Life and Evaluation of Symptoms Technology
Enhancing Medication Safety in Children With Polypharmacy Using Parent- Reported Symptom Assessments
Adolescent Surgery Roadmap Feasibility and Acceptability Study
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Electronic Patient-Reported Outcome-Based Interventions for Palliative Cancer Care: A Systematic and Mapping Review.JCO clinical cancer informatics · 2020Pooled it
- Impact of Specialized Pediatric Palliative Care: A Systematic Review.Journal of pain and symptom management · 2020Pooled it
- Patient-Reported Outcome Benefits for Children with Advanced Cancer and Parents: A Qualitative Study.Journal of pain and symptom management · 2023Trial
- Continuity of Cancer Care and Collaboration Between Family Physicians and Oncologists: Results of a Randomized Clinical Trial.Annals of family medicineTrial
- Outcome measurement tools in pediatric oncology palliative care: a scoping review of domains, validation and contextual relevance.BJC reports · 2026Review
- Adherence to daily electronic symptom screening in pediatric cancer: associations with time, location and pain.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Electronic Patient Reported Outcomes Measures (e-PROMs) in Pediatric Palliative Oncology Care: A Scoping Review.Journal of palliative care · 2024Article
- Barriers to and solutions for representative inclusion across the lifespan and in life course research: The need for structural competency highlighted by the COVID-19 pandemic.Journal of clinical and translational science · 2023Review
- End-of-life care quality for children with cancer who receive palliative care.Pediatric blood & cancer · 2022Article
- Article
- MyPref: pilot study of a novel communication and decision-making tool for adolescents and young adults with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Parent and Physician Understanding of Prognosis in Hospitalized Children With Advanced Heart Disease.Journal of the American Heart Association · 2021Article
- Parent-Reported Symptoms and Medications Used Among Children With Severe Neurological Impairment.JAMA network open · 2020Article
- Outcome Dimensions in Pediatric Palliative Care.Pediatrics · 2019Article
- Self-reported fatigue in children with advanced cancer: Results of the PediQUEST study.Cancer · 2018Article
- Symptom Monitoring in Pediatric Oncology Using Patient-Reported Outcomes: Why, How, and Where Next.The patient · 2018Article
- From the Child's Word to Clinical Intervention: Novel, New, and Innovative Approaches to Symptoms in Pediatric Palliative Care.Children (Basel, Switzerland) · 2018Article
- Emerging Methodologies in Pediatric Palliative Care Research: Six Case Studies.Children (Basel, Switzerland) · 2018Review
- Quality of Life in Children With Advanced Cancer: A Report From the PediQUEST Study.Journal of pain and symptom management · 2016Article
- Criteria for referring pediatric and adult patients with hematological diseases to palliative care: Consensus of the Brazilian Association of Hematology, hemotherapy and cell therapy (2025).Hematology, transfusion and cell therapyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
contextPediatric palliative care randomized controlled trials (PPC-RCTs) are uncommon.
objectivesTo evaluate the feasibility of conducting a PPC-RCT in pediatric cancer patients.
methodsThis was a cohort study embedded in the Pediatric Quality of Life and Evaluation of Symptoms Technology Study (NCT01838564). This multicenter PPC-RCT evaluated an electronic patient-reported outcomes system. Children aged two years and older, with advanced cancer, and potentially eligible for the study were included. Outcomes included: pre-inclusion attrition (patients not approached, refusals); post-inclusion attrition (drop-out, elimination, death, and intermittent attrition (IA; missing surveys) over nine months of follow-up); child/teenager self-report rates; and, reasons to enroll/participate.
resultsOver five years, of the 339 identified patients, 231 were eligible (in 22, we could not verify eligibility); 84 eligible patients were not approached and 43 declined participation. Patients not approached were more likely to die or have brain tumors. We enrolled 104 patients. Average enrollment rate was one patient per site per month; shortening follow-up from nine to three months (with optional re-enrollment) increased recruitment by 20%. A total of 87 patients completed the study (24 died) and 17 dropped out. Median IA was 41% in the first 20 weeks of follow-up and more than 60% in the eight weeks preceding death. Child/teenager self-report was 94%. Helping others, low burden procedures, incentives, and staff attitude were frequent reasons to enroll/participate.
conclusionA PPC-RCT in children with advanced cancer was feasible, post-inclusion retention adequate; many families participated for altruistic reasons. Strategies that may further PPC-RCT feasibility include: increasing target population through large multicenter studies, approaching sicker patients, preventing exclusion of certain patient groups, and improving data collection at end of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.