Evidence map›Paper›PMID 25640174›Full record

ArticleScientific reports2015

Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway.

Lijian Chen, Lijie Feng, Xia Wang, Jian Du, Ying Chen, Wen Yang, Chengyue Zhou, Li Cheng, Yujun Shen, Shengyun Fang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 117 citations in OpenAlex.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Lijian Chen1] School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China [3] Department of Anesthesiology of the First Affiliated Hospital, Anhui Medical University, Hefei 230022, Anhui, China.
Lijie Feng1] School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China.
Xia Wang1] School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China.
Jian Du1] School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China.
Ying ChenInstitute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China.
Wen Yang1] School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China.
Chengyue Zhou1] School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China.
Li Cheng1] School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China.
Yujun Shen1] School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China.
Shengyun Fang1] School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China [3] Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, MD 21201, USA.
Jun LiSchool of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China.
Yuxian Shen1] School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China [2] Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, Anhui, China.
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation can cause endoplasmic reticulum (ER) stress and therefore activates the unfolded protein response (UPR). ER stress and the consequent UPR have the potential to activate NF-κB. However, the factors mediating the crosstalk between ER stress and the NF-κB pathway remain unclear. Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models. Inflammation caused MANF to relocalize to the nuclei. MANF interacted with the DNA binding domain of p65 through its C-terminal SAP-like domain in the nuclei under the condition of inflammation or ER stress. MANF consequently inhibited p65-mediated transcriptional activation by interfering with the binding of p65 to its target genes promoters. Consistently, MANF suppressed the expressions of NF-κB-dependent target genes and the proliferation of inflammatory synoviocytes. These findings suggest that MANF may be a negative regulator of inflammation and mediate the crosstalk between the NF-κB pathway and ER stress.

Indexed as

AdultAgedAnimalsArthritisCell NucleusCell ProliferationCells, CulturedCell SurvivalEndoplasmic Reticulum StressFemaleHEK293 CellsHumansInflammationLupus Erythematosus, SystemicMaleMiddle AgedNerve Growth FactorsNF-kappa BRecombinant ProteinsRNA, Small InterferingTranscription Factor RelATumor Necrosis Factor-alpha

Identifiers

PMID25640174
PMCPMC4313098
OpenAlexW2025611086

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.