ArticleThe Journal of physiology2015
Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats.
Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Myostatin Knockout Mice Have Larger Muscle Fibers With Normal Function and Morphology.Muscle & nerve · 2025Article
- Effects of Myostatin on Nuclear Morphology at the Myotendinous Junction.International journal of molecular sciences · 2023Article
- Pulsed electromagnetic field therapy alters early healing in a rat model of rotator cuff injury and repair: Potential mechanisms.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Shoulder Lesions Do Not Increase Inflammatory Biomarkers in Patients Undergoing Surgery for Glenohumeral Instability: An Exploratory Study.Translational sports medicine · 2022Article
- Association of myostatin deficiency with collagen related disease-umbilical hernia and tippy toe standing in pigs.Transgenic research · 2021Article
- Factors Involved in Morphogenesis in the Muscle-Tendon-Bone Complex.International journal of molecular sciences · 2021Review
- Antimyostatin Treatment in Health and Disease: The Story of Great Expectations and Limited Success.Cells · 2021Review
- Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy.Connective tissue research · 2021Article
- Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models.Frontiers in genetics · 2021Review
- Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes.Journal of biomedical science · 2020Review
- The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy and Weakness After Rotator Cuff Tear.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Denervation and senescence markers data from old rats with intrinsic differences in responsiveness to aerobic training.Data in brief · 2019Article
- Prostaglandin DPhysiological reports · 2019Article
- Tendon healing in the context of complex fractures.Clinical reviews in bone and mineral metabolism · 2018Article
- Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training.Experimental physiology · 2018Article
- Pharmacological inhibition of myostatin protects against skeletal muscle atrophy and weakness after anterior cruciate ligament tear.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Sex differences in tendon structure and function.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Local cryotherapy minimally impacts the metabolome and transcriptome of human skeletal muscle.Scientific reports · 2017Article
- Regeneration of Skeletal Muscle After Eccentric Injury.Journal of sport rehabilitation · 2017Review
- Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Myostatin is a negative regulator of skeletal muscle and tendon mass. Myostatin deficiency has been well studied in mice, but limited data are available on how myostatin regulates the structure and function of muscles and tendons of larger animals. We hypothesized that, in comparison to wild-type (MSTN(+/+) ) rats, rats in which zinc finger nucleases were used to genetically inactivate myostatin (MSTN(Δ/Δ) ) would exhibit an increase in muscle mass and total force production, a reduction in specific force, an accumulation of type II fibres and a decrease and stiffening of connective tissue. Overall, the muscle and tendon phenotype of myostatin-deficient rats was markedly different from that of myostatin-deficient mice, which have impaired contractility and pathological changes to fibres and their extracellular matrix. Extensor digitorum longus and soleus muscles of MSTN(Δ/Δ) rats demonstrated 20-33% increases in mass, 35-45% increases in fibre number, 20-57% increases in isometric force and no differences in specific force. The insulin-like growth factor-1 pathway was activated to a greater extent in MSTN(Δ/Δ) muscles, but no substantial differences in atrophy-related genes were observed. Tendons of MSTN(Δ/Δ) rats had a 20% reduction in peak strain, with no differences in mass, peak stress or stiffness. The general morphology and gene expression patterns were similar between tendons of both genotypes. This large rodent model of myostatin deficiency did not have the negative consequences to muscle fibres and extracellular matrix observed in mouse models, and suggests that the greatest impact of myostatin in the regulation of muscle mass may not be to induce atrophy directly, but rather to block hypertrophy signalling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.