ArticleSingapore medical journal2015
Normalisation of urinary biomarkers to creatinine for clinical practice and research--when and why.
Article in Singapore medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Urinary CXCL-10, a prognostic biomarker for kidney graft injuries: a systematic review and meta-analysis.BMC nephrology · 2024Pooled it
- Recommendations of the Brazilian Society of Nephrology for the management of chronic kidney disease in primary health care.Jornal brasileiro de nefrologiaGuideline
- Eight weeks of MitoQ supplementation does not alter kidney function or urinary kidney injury biomarkers in middle-aged and older adults.American journal of physiology. Renal physiology · 2026Trial
- Article
- Mycotoxin exposure following an eight-week vegan or meat-rich dietary intervention: a randomized-controlled trial.NPJ science of food · 2026Article
- Review
- Urine dipstick test for assessing albumin-to-creatinine ratio: a pilot study and the potential impact on chronic kidney disease screening.BMC nephrology · 2026Article
- Creatinine Normalization Over-Corrects Urinary Electrolytes but Not Protein: Implications for Hydration Monitoring in Athletes.Metabolites · 2026Article
- Water intake mediates cross-sectional associations between urinary kidney injury biomarkers and race in emerging adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Metabolic Fingerprinting of Urine Reveals Metabolite Changes in Women With Breast Cancer.Cancer medicine · 2026Article
- Rethinking urinary tract infections in women with abdominal pain in pregnancy: a prospective case-control study.BMC pregnancy and childbirth · 2026Observational
- Article
- Article
- Integrating TMAO into the pathogenesis of obesity and type 2 diabetes: a mini review.Frontiers in clinical diabetes and healthcare · 2026Review
- Urine inflammatory protein levels decrease following kidney transplantation.Frontiers in medicine · 2026Article
- Article
- Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection.NPJ biofilms and microbiomes · 2025Article
- Hypohydration augments the acute increase in urinary biomarkers of kidney injury following the 100-mile Western States Endurance Run.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Response to "Uromodulin in pediatric CKD patients: Lessons unlearned regarding blood pressure".Pediatric nephrology (Berlin, Germany) · 2025Article
- Statistical consideration in nephrology research.Kidney research and clinical practice · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) and chronic kidney disease (CKD) are major health problems. Urinary biomarkers have both diagnostic and prognostic utility in AKI and CKD. However, how biomarker excretion rates should be reported, especially whether they should be normalised to urinary creatinine concentration (uCr), is controversial. Some studies suggest that normalisation to uCr may be inappropriate at times, as urinary creatinine excretion rate may vary greatly, depending on the situation. Notably, recent studies suggest that while normalisation of values to UCr may be valid for the evaluation of CKD and prediction of AKI sequelae and occurrences, it could be inappropriate for the diagnosis of AKI, or in the presence of certain acute kidney disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.