ArticleMedical science monitor : international medical journal of experimental and clinical research2015
Parameters of dynamic contrast-enhanced MRI as imaging markers for angiogenesis and proliferation in human breast cancer.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Can apparent diffusion coefficient (ADC) distinguish breast cancer from benign breast findings? A meta-analysis based on 13 847 lesions.BMC cancer · 2019Pooled it
- Hyperbaric oxygen can induce angiogenesis and recover erectile function.International journal of impotence research · 2018Trial
- Amide proton transfer-weighted magnetic resonance imaging for the diagnosis of triple-negative breast cancer: a comparative study with diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Breast edema score as a biomarker of tumor aggressiveness and its predictive value for neoadjuvant chemotherapy response.European radiology · 2026Article
- Physics-based simulation of ultrasound propagation from MRI volumes for cross-modal breast imaging.Journal of biological engineering · 2026Article
- Diagnostic value of IVIM and DCE-MRI parameters for differentiating benign from malignant bone tumors and their correlations with Ki-67 expression.BMC cancer · 2026Article
- Value of Radiomics Based on DCE-MRI in distinguishing benign and malignant breast lesions: Predicting Histological Grade and Lymph Node Metastasis of Breast Cancer.Pakistan journal of medical sciences · 2026Article
- Multiparametric MRI deep learning model based on dynamic Contrast-enhanced and apparent diffusion coefficient map enables accurate prediction of benign and malignant breast lesions.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging and Positron Emission Tomography (PET) for Distinguishing Metastatic Lymph Nodes from Nonmetastatic Among Patients with Rectal Cancer: A Systematic Review and Meta-Analysis.World journal of nuclear medicine · 2025Article
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- Advances in non-invasive imaging for dermatofibrosarcoma protuberans: A review.The Australasian journal of dermatology · 2024Review
- Review
- Multiparametric MRI-based radiomic nomogram for predicting HER-2 2+ status of breast cancer.Heliyon · 2024Article
- Advances in fibreoptic ductoscopy for the diagnosis and treatment of pathologic papillary overflow.Heliyon · 2024Review
- Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer.Scientific reports · 2023Article
- Dynamic contrast-enhanced magnetic resonance imaging radiomics analysis based on intratumoral subregions for predicting luminal and nonluminal breast cancer.Quantitative imaging in medicine and surgery · 2023Article
- Quantitative dynamic contrast-enhance MRI parameters for rectal carcinoma characterization: correlation with tumor tissue composition.World journal of surgical oncology · 2023Article
- PET/MRI of hypoxia and vascular function in ER-positive breast cancer: correlations with immunohistochemistry.European radiology · 2023Article
- Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer.Medicina (Kaunas, Lithuania) · 2023Article
- Towards detection of early response in neoadjuvant chemotherapy of breast cancer using Bayesian intravoxel incoherent motion.Frontiers in oncology · 2023Article
15 more citing papers are in PubMed but not listed here.
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7 authors at 1 institution in 1 country.
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Abstract
backgroundBreast cancer is the most common malignancy and the leading cause of cancer death in women worldwide; however, early diagnosis has been difficult due to its complex pathological structure. This study evaluated the value of morphological examination in conjunction with dynamic contrast-enhanced MRI (DCE-MRI) for more precise diagnosis of breast cancer, as well as their correlation with angiogenesis and proliferation biomarkers. MATERIAL/
methodsDCE-MRI parameters (including Ktrans: volume transfer coefficient reflecting vascular permeability, Kep: flux rate constant, Ve: extracellular volume ratio reflecting vascular permeability, and ADC: apparent diffusion coefficient) were obtained from 124 patients with breast cancer (124 lesions). Microvessel density (MVD) was evaluated by the immunohistochemical analysis of tumor vessels for CD31 and CD105 expression. The proliferation was assessed by analyzing Ki67.
resultsKtrans values were in the order of: malignant lesions>benign lesions>normal glands. Similar results were observed for Kep. The opposite changes were seen with Ve. Ktrans and Kep values were significantly higher in invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS) than in mammary ductal dysplasia (MDD; ANOVA followed by Dunnett's test). In sharp contrast, ADC values were lower in IDC and DCIS than in MDD, and Ve was not significantly different among the three groups. The data from MIP (maximum intensity projection) showed that benign breast lesions had no or only one blood vessel, whereas malignant lesions had two or more blood vessels. In addition, expression of CD105 and Ki67, the commonly recognized markers for angiogenesis and proliferation, respectively, were closely correlated with MRI parameters as revealed by Pearson analysis.
conclusionsDetermination of Ktrans, Kep and ADC values permits estimation of tumor angiogenesis and proliferation in breast cancer and DCE-MRI parameters can be used as imaging biomarkers to predict patient prognosis and the biologic aggressiveness of the tumor.
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