ArticleNeuron2015
Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory receptor orthologs and pharyngeal neurons.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 172 citations in OpenAlex.
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- Non-visual light modulates behavioral memory and gene expression inbioRxiv : the preprint server for biology · 2025Article
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- Blue light stimulated-autofluorescence green flash of lysosome-related organelles in the intestinal cells of nematodes.G3 (Bethesda, Md.) · 2025Article
- Blue light stimulated-autofluorescence green flash of lysosome-related organelles in the intestinal cells of nematodes.bioRxiv : the preprint server for biology · 2025Article
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- Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2025Article
- An enteric neuron-expressed variant ionotropic receptor detects ingested salts to regulate salt stress resistance.bioRxiv : the preprint server for biology · 2025Article
- Neuronal PRDX-2-Mediated ROS Signaling Regulates Food Digestion via peripheral UPRNature communications · 2024Article
- cGMP-dependent pathway and a GPCR kinase are required for photoresponse in the nematode Pristionchus pacificus.PLoS genetics · 2024Article
- TWISP: a transgenic worm for interrogating signal propagation in Caenorhabditis elegans.Genetics · 2024Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
While gustatory sensing of the five primary flavors (sweet, salty, sour, bitter, and savory) has been extensively studied, pathways that detect non-canonical taste stimuli remain relatively unexplored. In particular, while reactive oxygen species cause generalized damage to biological systems, no gustatory mechanism to prevent ingestion of such material has been identified in any organism. We observed that light inhibits C. elegans feeding and used light as a tool to uncover molecular and neural mechanisms for gustation. Light can generate hydrogen peroxide, and we discovered that hydrogen peroxide similarly inhibits feeding. The gustatory receptor family members LITE-1 and GUR-3 are required for the inhibition of feeding by light and hydrogen peroxide. The I2 pharyngeal neurons increase calcium in response to light and hydrogen peroxide, and these responses require GUR-3 and a conserved antioxidant enzyme peroxiredoxin PRDX-2. Our results demonstrate a gustatory mechanism that mediates the detection and blocks ingestion of a non-canonical taste stimulus, hydrogen peroxide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.