Evidence map›Paper›PMID 25640030›Full record

ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015

Tendon functional extracellular matrix.

Hazel R C Screen, David E Berk, Karl E Kadler, Francesco Ramirez, Marian F Young

Open access · greenAbstract readReview
In one paragraph

Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 1 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 1 synthesis or guideline pooled it, 256 citations in OpenAlex.

  1. Pooled it
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  13. Developmental, but not Homeostatic, Collagen V Expression Regulates Mature Murine Supraspinatus Tendon Structure, Function, and Gene Expression.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Hazel R C ScreenInstitute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom.
David E Berk
Karl E Kadler
Francesco Ramirez
Marian F Young
Jefferson College · USNational Institutes of Health · USQueen Mary University of London · GBUniversity of Manchester · GBUniversity of South Florida · US

Funding

Function Of Skeletal Matrix GenesZIADE000379 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI YOUNG, MARIAN F · 2009 to 2023
$23.6M
Regulated Assembly of the Tendon Extracellular MatrixR01AR044745 · NIAMS · UNIVERSITY OF SOUTH FLORIDA · PI BIRK, DAVID E · 1997 to 2016
$5.0M
Injury Response in Normal and EDS Tendons: Regulatory Roles of Collagen VR01AR065995 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BIRK, DAVID E, SOSLOWSKY, LOUIS J · 2014 to 2018
$1.8M
Arthritis Research UKBiotechnology and Biological Sciences Research CouncilNIAMS NIH HHS AR044745NIAMS NIH HHS AR065995NIAMS NIH HHS R01 AR044745NIAMS NIH HHS R01 AR065995Wellcome Trust
6 · The paper itself

Abstract

This article is one of a series, summarizing views expressed at the Orthopaedic Research Society New Frontiers in Tendon Research Conference. This particular article reviews the three workshops held under the "Functional Extracellular Matrix" stream. The workshops focused on the roles of the tendon extracellular matrix, such as performing the mechanical functions of tendon, creating the local cell environment, and providing cellular cues. Tendon is a complex network of matrix and cells, and its biological functions are influenced by widely varying extrinsic and intrinsic factors such as age, nutrition, exercise levels, and biomechanics. Consequently, tendon adapts dynamically during development, aging, and injury. The workshop discussions identified research directions associated with understanding cell-matrix interactions to be of prime importance for developing novel strategies to target tendon healing or repair.

Indexed as

AnimalsExtracellular MatrixHumansTendonscellcollagenhierarchymechanicsproteoglycansstructuretendinopathytenocyte

Identifiers

PMID25640030
PMCPMC4507431
OpenAlexW1890735177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.