ArticleExperimental gerontology2015
Effect of in vivo loading on bone composition varies with animal age.
Article in Experimental gerontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Methodological aspects ofJournal of musculoskeletal & neuronal interactions · 2023Pooled it
- Biomechanical comparison of mini-plate and screw fixation in minimally invasive distal metatarsal osteotomy for hallux valgus : a finite element and cadaveric study.Bone & joint research · 2026Article
- Article
- The specialist in regeneration-the Axolotl-a suitable model to study bone healing?NPJ Regenerative medicine · 2022Article
- Poor bone matrix quality: What can be done about it?Current osteoporosis reports · 2021Review
- Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters.Scientific reports · 2021Article
- The Effect of Ethanol Consumption on Composition and Morphology of Femur Cortical Bone in Wild-Type and ALDH2*2-Homozygous Mice.Calcified tissue international · 2021Article
- Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Aging and Mechanoadaptive Responsiveness of Bone.Current osteoporosis reports · 2019Review
- Treadmill running and targeted tibial loading differentially improve bone mass in mice.Bone reports · 2019Article
- Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression.Scientific reports · 2017Article
- Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Loading can increase bone mass and size and this response is reduced with aging. It is unclear, however how loading affects bone mineral and matrix properties. Fourier transform infrared imaging and high resolution synchrotron scanning small angle X-ray scattering were used to study how bone's microscale and nanoscale compositional properties were altered in the tibial midshaft of young, adult, and elderly female C57Bl/6J mice after two weeks of controlled in vivo compressive loading in comparison to physiological loading. The effect of controlled loading on bone composition varied with animal age, since it predominantly influenced the bone composition of elderly mice. Interestingly, controlled loading led to enhanced collagen maturity in elderly mice. In addition, although the rate of bone formation was increased by controlled loading based on histomorphometry, the newly formed tissue had similar material quality to the new bone tissue formed during physiological loading. Similar to previous studies, our data showed that bone composition was animal age- and tissue age-dependent during physiological loading. The findings that the new tissue formed in response to controlled loading and physiological loading had similar bone composition and that controlled loading enhanced bone composition in elderly mice further support the use of physical activity as a noninvasive treatment to enhance bone quality as well as maintain bone mass in individuals suffering from age-related bone loss.
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Registered trials
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