ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015
Dance between biology, mechanics, and structure: A systems-based approach to developing osteoarthritis prevention strategies.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The trial behind it
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Who cites it
52 citing papers in PubMed.
- Immediate Biochemical Changes After Gait Biofeedback in Individuals With Anterior Cruciate Ligament Reconstruction.Journal of athletic training · 2020Trial
- Evaluation of Pre-Operative Cartilage and Meniscus Ultrashort Echo Time T2* as Biomarkers of Long-Term Clinical Outcomes Following Anterior Cruciate Ligament Reconstruction.Journal of magnetic resonance imaging : JMRI · 2026Article
- Perspective: One and one make three - leveraging the synergy of imaging and biomechanics in osteoarthritis research and care.Osteoarthritis imaging · 2026Article
- Multivariate Analysis of Inflammatory and Regenerative Mediators in an In Vitro Canine Osteoarthritis System Treated with Platelet Gel Supernatants.Gels (Basel, Switzerland) · 2026Article
- Preventing osteoarthritis after anterior cruciate ligament injury: The case for targeting pre-osteoarthritis illness.Osteoarthritis and cartilage · 2026Article
- Gait Biomechanical Differences in the Anterior Cruciate Ligament Reconstructed and Contralateral Limb: A Systematic Review with Meta-Analysis.Healthcare (Basel, Switzerland) · 2025Review
- A Multidimensional Definition of Pre-Osteoarthritis: Toward 21st-Century Subclinical Detection and Targeted Intervention.International journal of molecular sciences · 2025Review
- 2050: An Arthroplasty Odyssey.Healthcare (Basel, Switzerland) · 2025Article
- Transformative approaches for effective clinical trials to reduce the disease burden of osteoarthritis.Seminars in arthritis and rheumatism · 2025Review
- Preoperative Platelet-Rich Plasma Injections Decrease Inflammatory and Chondrodegenerative Biomarkers in Patients With Acute Anterior Cruciate Ligament Tears: A Pilot Randomized Controlled Trial.Orthopaedic journal of sports medicine · 2025Article
- Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre- and early-stage osteoarthritis in a rodent model.Scientific reports · 2024Article
- Ultrasound-detected effusion-synovitis is associated with greater limb loading rate asymmetry during walking post-ACL reconstruction: A pilot study.Osteoarthritis imaging · 2024Article
- Immediate Effects of Walking With a Knee Brace After Anterior Cruciate Ligament Reconstruction: A Biomechanical, Biochemical, and Structural Approach.Journal of athletic training · 2023Article
- Body mass affects kinetic symmetry and inflammatory markers in adolescent knees during gait.Clinical biomechanics (Bristol, Avon) · 2023Article
- Patellofemoral contact forces and knee gait mechanics 3 months after ACL reconstruction are associated with cartilage degradation 24 months after surgery.Osteoarthritis and cartilage · 2023Article
- Knee joint biomechanics during gait improve from 3 to 6 months after anterior cruciate ligament reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Progress in osteoarthritis research by the National Natural Science Foundation of China.Bone research · 2022Review
- Linking Gait Biomechanics and Daily Steps After ACL Reconstruction.Medicine and science in sports and exercise · 2022Article
- Patellofemoral contact forces after ACL reconstruction: A longitudinal study.Journal of biomechanics · 2022Article
- Knee cartilage TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Osteoarthritis (OA) is a leading cause of human suffering and disability for which disease-modifying treatments are lacking. OA occurs through complex and dynamic interplays between diverse factors over long periods of time. The traditional research and clinical focus on OA, the end stage disease, obscured understanding pathogenesis prior to reaching a common pathway defined by pain and functional deficits, joint deformity, and radiographic changes. To emphasize disease modification and prevention, we describe a multi-disciplinary systems-based approach encompassing biology, mechanics, and structure to define pre-osteoarthritic disease processes. Central to application of this model is the concept of "pre-osteoarthritis," conditions where clinical OA has not yet developed. Rather, joint homeostasis has been compromised and there are potentially reversible markers for heightened OA risk. Key messages from this perspective are (i) to focus research onto defining pre-OA through identifying and validating biological, mechanical, and imaging markers of OA risk, (ii) to emphasize multi-disciplinary approaches, and (iii) to propose that developing personalized interventions to address reversible markers of OA risk in healthy joints may be the key to prevention. Ultimately, a systems-based analysis of OA pathogenesis shows potential to transform clinical practice by facilitating development and testing of new strategies to prevent or delay the onset of osteoarthritis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.