Evidence map›Paper›PMID 25639724›Full record

ArticleNano letters2015

Fabrication of micropatterned polymeric nanowire arrays for high-resolution reagent localization and topographical cellular control.

Cade B Fox, Jean Kim, Erica B Schlesinger, Hariharasudhan D Chirra, Tejal A Desai

Abstract read
In one paragraph

Article in Nano letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. On the Interaction between 1D Materials and Living Cells.Journal of functional biomaterials · 2020
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Micro/nanofabricated platforms for oral drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2015
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cade B FoxDepartment of Bioengineering and Therapeutic Sciences, University of California , San Francisco, California 94158, United States.
Jean Kim
Erica B Schlesinger
Hariharasudhan D Chirra
Tejal A Desai

Funding

UCSF/UCB Joint Graduate Group in BIoengineeringT32GM008155 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DESAI, TEJAL A. · 1985 to 2020
$12.2M
PHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1M
Mechanisms of nanostructure-enhanced transepithelial drug deliveryR01EB018842 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DESAI, TEJAL A. · 2014 to 2017
$1.4M
NIBIB NIH HHS R01 EB018842NIGMS NIH HHS 5T32GM007175-37NIGMS NIH HHS T32 GM007175NIGMS NIH HHS T32 GM008155NIGMS NIH HHS T32GM008155-29
6 · The paper itself

Abstract

Herein, we present a novel approach for the fabrication of micropatterned polymeric nanowire arrays that addresses the current need for scalable and customizable polymer nanofabrication. We describe two variations of this approach for the patterning of nanowire arrays on either flat polymeric films or discrete polymeric microstructures and go on to investigate biological applications for the resulting polymeric features. We demonstrate that the micropatterned arrays of densely packed nanowires facilitate rapid, low-waste drug and reagent localization with micron-scale resolution as a result of their high wettability. We also show that micropatterned nanowire arrays provide hierarchical cellular control by simultaneously directing cell shape on the micron scale and influencing focal adhesion formation on the nanoscale. This nanofabrication approach has potential applications in scaffold-based cellular control, biological assay miniaturization, and biomedical microdevice technology.

Indexed as

bio-MEMSbioscaffoldsdrug loadingNanofabricationnanowirespolycaprolactone

Identifiers

PMID25639724
PMCPMC4664059

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.