ReviewJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2015
Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep.
Review in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04281264 (Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review.International journal of environmental research and public health · 2019Pooled it
- Association between sleep apnea and low bone mass in adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Bone Turnover Markers After Sleep Restriction and Circadian Disruption: A Mechanism for Sleep-Related Bone Loss in Humans.The Journal of clinical endocrinology and metabolism · 2017Trial
- Linking sleep apnea and arthritis in the National Alzheimer Coordinating Center Cohort: A cross-sectional analysis.Medicine · 2026Article
- HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm.Bone research · 2026Review
- Association Between Sleep Quality and Geriatric Hip Fracture: A Prospective Comparative Study.Geriatric orthopaedic surgery & rehabilitation · 2026Article
- Age-dependent association between obstructive sleep apnea and self-reported history of fractures: a community-based study.BMC public health · 2025Article
- Association between vertebral fracture risk and bone mineral density in patients with acromegaly.Pituitary · 2025Article
- Association between sleep duration, sleep apnea risk, and osteoporosis in older adults: a cross-sectional study in elder care institutions in Taiwan.BMC geriatrics · 2025Article
- Review
- Obstructive Sleep Apnoea and Risk of Fragility Fracture in Patients With Type 2 Diabetes: A Population-Based Retrospective Cohort Study.Endocrinology, diabetes & metabolism · 2025Article
- High prevalence of vertebral fractures associated with apnea-hypopnea index in patients with recent diagnosis of obstructive sleep apnea.BMC musculoskeletal disorders · 2025Article
- AZU1 as a DNA Methylation-Driven Gene: Promoting Oxidative Stress in High-Altitude Pulmonary Edema.Antioxidants (Basel, Switzerland) · 2025Article
- Association of triglyceride-glucose index with all-cause and non-cardiovascular mortality in patients with obstructive sleep apnea: an age-stratified analysis.Diabetology & metabolic syndrome · 2025Article
- Effects of stress on bone health in children.Frontiers in endocrinology · 2025Review
- AI-driven bone mineral density prediction from chest x-rays and its association with obstructive sleep apnea.PloS one · 2025Article
- Factors Associated with Non-Unions of Fifth Metatarsal Fractures.The archives of bone and joint surgery · 2025Article
- 24-hour activity composition is associated with lower fall and fracture risk in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Association of obstructive sleep apnea with bone metabolism in older adults: a hospital-based study.BMC musculoskeletal disorders · 2024Article
- The role of Klotho and sirtuins in sleep-related cardiovascular diseases: a review study.npj aging · 2024Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
Obstructive sleep apnea (OSA) and low bone mass are two prevalent conditions, particularly among older adults-a section of the U.S. population that is expected to grow dramatically over the coming years. OSA, the most common form of sleep-disordered breathing, has been linked to multiple cardiovascular, metabolic, hormonal, and inflammatory derangements and may have adverse effects on bone. However, little is known about how OSA (including the associated hypoxia and sleep loss) affects bone metabolism. In order to gain insight into the relationship between sleep and bone, we review the growing information on OSA and metabolic bone disease and discuss the pathophysiological mechanisms by which OSA may affect bone metabolism/architecture.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.