ReviewScience progress2014
The transition from iron starvation to iron sufficiency as an important step in the progression of infection.
Review in Science progress, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Effect of the Extracellular Vesicle RNA Cargo From UropathogenicFrontiers in molecular biosciences · 2020Article
- Article
- Analysis of theJournal of extracellular vesicles · 2019Article
- Isolation of membrane vesicles from prokaryotes: a technical and biological comparison reveals heterogeneity.Journal of extracellular vesicles · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is an essential micronutrient for microbial life. At the start of an infection the host environment will normally restrict available iron, and innate immune responses will aim to further reduce iron, thus inhibiting growth of potential pathogens. Successful pathogens have developed a variety of mechanisms to acquire iron from the available in vivo sources, using remote and direct capture, to render their environment iron replete. Iron restriction, and the presence of host iron sources like haem, are important drivers of gene regulation controlling the expression of numerous virulence factors. As an infection progresses the changing iron environment will therefore influence pathogen gene expression and trigger new activities. Understanding how bacteria acquire iron, and how iron acquisition affects the bacteria, has identified vaccine and antibiotic drug targets and is now suggesting novel approaches to control and treat infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.