ArticleActa biomaterialia2015
Phase stability and biological property evaluation of plasma sprayed hydroxyapatite coatings for orthopedic and dental applications.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 188 citations in OpenAlex.
- Curcumin-loaded alkali-heat-treated titanium modulates macrophage inflammatory responses.Biomaterials science · 2026Article
- Antibacterial and Immunomodulatory Coatings for Orthopedic Metal Implants: Biological Rationale, Design Strategies, and Translational Challenges.Advanced healthcare materials · 2026Review
- Organic Acid-Based Anodization Process to Produce Bioactive Oxides on Titanium Implants.Materials (Basel, Switzerland) · 2025Article
- EnhancedACS applied bio materials · 2025Article
- Citrus-Fruit-Based Hydroxyapatite Anodization Coatings on Titanium Implants.Materials (Basel, Switzerland) · 2025Article
- Hydroxyapatite-based coatings on Mg and Ti-based implants: A detailed examination of various coating methodologies.Heliyon · 2025Review
- Facile universal strategy of presenting multifunctional short peptides for customizing desired surfaces.Journal of nanobiotechnology · 2025Article
- Review
- Natural medicine delivery from 3D printed bone substitutes.Journal of controlled release : official journal of the Controlled Release Society · 2024Review
- Hydroxyapatite coated titanium with curcumin and epigallocatechin gallate for orthopedic and dental applications.Biomaterials advances · 2023Article
- Improving Biocompatibility for Next Generation of Metallic Implants.Progress in materials science · 2023Article
- Hydrothermal Synthesis of Fluorapatite Coatings over Titanium Implants for Enhanced Osseointegration-An In Vivo Study in the Rabbit.Journal of functional biomaterials · 2022Article
- Article
- Ginger and Garlic Extracts Enhance Osteogenesis in 3D Printed Calcium Phosphate Bone Scaffolds with Bimodal Pore Distribution.ACS applied materials & interfaces · 2022Article
- Modification of the surface nanotopography of implant devices: A translational perspective.Materials today. Bio · 2021Review
- Behavior of rat bone marrow stem cells on titanium surfaces modified by laser-beam and deposition of calcium phosphate.Journal of materials science. Materials in medicine · 2021Article
- ZnO Nanosheet-Coated TiZrPdSiNb Alloy as a Piezoelectric Hybrid Material for Self-Stimulating Orthopedic Implants.Biomedicines · 2021Article
- Enhanced osteogenesis properties of titanium implant materials by highly uniform mesoporous thin films of hydroxyapatite and titania intermediate layer.Journal of materials science. Materials in medicine · 2020Article
- Natural Antibiotic Oregano in Hydroxyapatite-Coated Titanium Reduces Osteoclastic Bone Resorption for Orthopedic and Dental Applications.ACS applied materials & interfaces · 2020Article
- Effects of vitamin C on osteoblast proliferation and osteosarcoma inhibition using plasma coated hydroxyapatite on titanium implants.Surface & coatings technology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In this work we have investigated the effects of strontium (Sr) dopant on in vitro protein release kinetics and in vivo osteogenic properties of plasma sprayed hydroxyapatite (HA) coatings, along with their dissolution behavior. Plasma sprayed HA coatings are widely used in load-bearing implants. Apart from osseointegration, the new generation of HA coating is expected to deliver biomolecules and/or drugs that can induce osteoinduction. This paper reports the preparation of crystalline and amorphous HA coatings on commercially pure titanium (Cp-Ti) using inductively coupled radio frequency (RF) plasma spray, and their stability at different solution pH. Coatings prepared at 110 mm working distance from the nozzle showed an average Ca ion release of 18 and 90 ppm in neutral and acidic environments, respectively. Decreasing the working distance to 90 mm resulted in the formation of a coating with less crystalline HA and phases with higher solubility products, and consequently higher dissolution over 32 days. A 92% release of a model protein bovine serum albumin (BSA) in phosphate buffer with pH of 7.4 was measured for Sr-doped HA (Sr-HA) coating, while only a 72% release could be measured for pure HA coating. Distortion of BSA during adsorption on coatings revealed a strong interaction between the protein and the coating, with an increase in α-helix content. Osteoid formation was found on Sr-HA implants as early as 7 weeks post implantation compared to HA coated and uncoated Ti implants. After 12 weeks post implantation, osteoid new bone was formed on HA implants; whereas, bone mineralization started on Sr-HA samples. While no osteoid was formed on bare Ti surfaces, bone was completely mineralized on HA and Sr-HA coatings after 16 weeks post implantation. Our results show that both phase stability and chemistry can have a significant influence toward in vitro and in vivo response of HA coatings on Ti implants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.